Methylation of cell-free DNA in the diagnosis of cancer

Image   A range of molecular alterations found in tumor cells, such as DNA mutations and DNA methylation, is reflected in cell-free circulating DNA (circDNA) released from the tumor into the blood, thereby making circDNA an ideal candidate for the basis of a blood-based cancer diagnosis test. In many cancer types, mutations driving tumor development and progression are present in a wide range of oncogenes and tumor suppressor genes. However, even when a gene is consistently mutated in a particular cancer, the mutations can be spread over very large regions of its sequence, making evaluation difficult. This diversity of sequence changes... Read More

Higher dyslipidemia rates among women living with HIV

Image Antiretroviral combination therapy (cART) has increased the service life of People live on HIV (PLWH). As long-term survival rises, PLWH may have metabolic and cardiovascular disorders such as diabetes, cardiovascular disease, obesity, metabolic syndrome, and dyslipidaemia more often than others. Moreover, although persons receiving cART have fewer AIDS-related diseases than cART-na€ıve PLWH overall, exposure to cART, particularly protease inhibitors (PIs), may increase the risk of cardiometabolic disease. One research found no substantial difference in the incidence of diabetes between WLWH and HIV-negative women among women living with HIV (WLWH), while another recorded a lower prevalence of hypertension but an elevated... Read More

AIDS-associated Talaromyces marneffei central nervous system infection

Image Talaromyces marneffei (T. marneffei, also known as Penicillium marneffei) is a regional opportunistic fungus that mainly causes life-threatening disseminated infection of the acquired immunodeficiency syndrome (AIDS) that causes epidemics in Southeast Asia and South China. The thermally dimorphic fungi invade mainly the skin, lungs, liver, spleen, lymph nodes and the circulatory system. Central nervous system (CNS) infection is extremly rare. At present, there are only 22 AIDS-associated cases T. CNS infection of marneffei and two sporadic cases of non-AIDS patients with T. Infection with CNS marneffei has been documented worldwide. These two patients who had not had AIDS suffered from... Read More

AIDS Orphans

Image The number of orphans living with AIDS has grown. By the end of the last century, 13.2 million children were estimated to have lost either a mother or both parents to AIDS, with the statistics potentially increasing. 95 percent of those children live in sub-Saharan Africa. It had also been estimated that there would be 1 million AIDS orphans in South Africa by 2005 and 2.5 million by 2010. The impact of the HIV / AIDS virus has been crucially affected by the household economy. The situation deteriorates still further when the AIDS sufferer dies. Migration and urbanization have also... Read More

Methylation of cell-free circulating DNA in the diagnosis of cancer

Image A range of molecular alterations found in tumour cells, such as DNA mutations and DNA methylation, is reflected in cell-free circulating DNA (circDNA) released from the tumour into the blood, thereby making circDNA an ideal candidate for the basis of a blood-based cancer diagnosis test. In many cancer types, mutations driving tumor development and progression are present in a wide range of oncogenes and tumor suppressor genes. However, even when a gene is consistently mutated in a particular cancer, the mutations can be spread over very large regions of its sequence, making evaluation difficult. This diversity of sequence changes in... Read More

A porcine model system of BRCA1 driven breast cancer

Image BRCA1 is a breast and ovarian tumour suppressor. Hereditary mutations in BRCA1 result in a predisposition to breast cancer, and BRCA1 expression is down-regulated in ~30% of sporadic cases. The function of BRCA1 remains poorly understood, but it appears to play an important role in DNA repair and the maintenance of genetic stability. Mouse models of BRCA1 deficiency have been developed in an attempt to understand the role of the gene in vivo. However, the subtle nature of BRCA1 function and the well-known discrepancies between human and murine breast cancer biology and genetics may limit the utility of mouse systems in... Read More

Global HIV-AIDS epidemiology

Image Globally, sexual transmission is the dominant mode of HIV spread, with a concomitant epidemic in infants born to HIV-infected mothers. HIV is also spread through contaminated blood, either through sharing of needles and syringes used for illicit intravenous drugs, transfusion of blood and blood products, or contaminated needles and equipment in medical care settings. The differential distribution of HIV worldwide is partly explained by the fact that not all modes of transmission of HIV carry the same risk. Studies have shown that the risk of HIV transmission from male to female is greater than that of transmission from female to... Read More

COVID-19 in HIV-Infected People

Image Coronaviruses are a large family of viruses which may cause illness in animals or humans. COVID-19 is the name given to the infectious disease caused by the most recently discovered novel coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This new virus and disease were unknown before the outbreak began in Wuhan, China, in December 2019. Not everyone who is infected with SARS-CoV-2 will end up getting sick with the disease, COVID-19, and people can have anything from no symptoms at all to being mildly sick or severely ill. There is actually no reason to suggest that people infected... Read More

Neurological disorders in HIV

Image Neurological diseases (NDs) are caused by three primary pathways in individuals diagnosed with HIV, overt HIV transmission, opportunistic processes arising from the lack of cell-mediated immunity, and inflammation or autoimmunity. While they occur during all stages of HIV infection, they occur most frequently in advanced HIV disease where their overall pattern and frequency at clinical presentation reflects mostly the level of immunity of the individual and previous exposure to the environment. Human immunodeficiency virus is the virus which causes the syndrome of acquired immune deficiency. HIV affects the immune system by killing unique white blood cells known as CD4-positive (CD4... Read More

HIV AIDS and Young peoples

Image AIDS is the leading cause of death among young people in Africa (10-24 years old) and the world's second leading cause. Young women become twice as likely as young men to acquire HIV. A youth bulge is threatening to further increase new HIV infections in Africa. In 2018, youth aged 13 to 24 years represented 21 percent of the 37,832 new HIV diagnoses in the United States (US) and dependent areas. Youth with HIV are the least likely to be cared for in any age group and have a viral load suppressed. Addressing HIV in young adults ensures that young... Read More

The role of NK cells and innate lymphoid cells in brain cancer

Image The brain is considered an immune privileged site due to the high selectivity of the blood-brain barrier which restricts the passage of molecules and cells into the brain parenchyma. Recent studies have highlighted active immunosurveillance mechanisms in the brain. Here we review emerging evidence for the contribution of innate lymphoid cells (ILCs) including natural killer (NK) cells to the immunosurveillance of brain cancers focusing on glioblastoma, one of the most aggressive and most common malignant primary brain tumors diagnosed in adults. Moreover, we discuss how the local tissue microenvironment and unique cellular interactions influence ILC functions in the brain and... Read More

HIV Screening Test

Image A HIV test shows if you have HIV infection (human immunodeficiency virus). HIV is a virus that attacks the immune system and destroys cells. These cells protect your body from germs which cause disease, such as bacteria and viruses. If you lack so many red cells, it can give your body problems fighting off pathogens and other diseases. An HIV test is used to determine if you had HIV infection. HIV (acquired immunodeficiency syndrome) is the virus that causes AIDS. Most HIV-patients do not have AIDS. People with AIDS have an extremely low number of immune cells and are at... Read More

Diffusion of intraperitoneal chemotherapy in women with advanced ovarian cancer in community settings 2003–2008: the effect of the NCI clinical recommendation

Image Purpose: A 2006 National Cancer Institute clinical announcement recommended the use of combined intravenous (IV) and intraperitoneal (IP) chemotherapy over IV chemotherapy alone for women with International Federation of Gynaecology and Obstetrics (FIGO) stage 3 optimally debulked ovarian cancer due to significant survival benefit demonstrated in multiple randomized clinical trials. We examined uptake of IP chemotherapy in community practice before and after this recommendation. Methods: We identified 288 women with FIGO stage 2 or greater incident ovarian cancer diagnosed from 2003 to 2008 at three integrated delivery systems in the US. Administrative health plan data were used to determine patient characteristics and... Read More

Immunotherapy in People with HIV and Cancer

Image HIV infection alters the natural history of several cancers, in large part due to its effect on the immune system. Immune function in people living with HIV may vary from normal to highly dysfunctional and is largely dependent on the timing of initiation (and continuation) of effective antiretroviral therapy (ART). An individual's level of immune function in turn affects their cancer risk, management, and outcomes. HIV-associated lymphocytopenia and immune deregulations permit immune evasion of oncogenic viruses and premalignant lesions and are associated with inferior outcomes in people with established cancers. Various types of immunotherapy, including monoclonal antibodies, interferon, cytokines,... Read More

International quality in HIV / AIDS study

Image Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) are global burden of health. Adherence to medicine is a crucial factor in reducing morbidity and mortality of people living with HIV (PLWH). It is estimated that 36.7 million people worldwide are diagnosed with HIV and that about one million died worldwide from causes linked to HIV. There is actually no treatment for the HIV infection. Efficient antiretroviral therapy (ART) is therefore considered the best treatment suitable for people living with HIV (PLWH) and those at serious risk. Preventing and managing HIV infection relies primarily on commitment to prescribed care. Weak... Read More

HIV / AIDS and Environment

Image In many rural areas of developed countries, local natural resources are an important means of livelihood and income production. Local environment health can also in at least two ways shape individual vulnerability to HIV / AIDS. The age profile of people who die from AIDS shapes the effects of the pandemic at home level. In developing countries, AIDS deaths are concentrated in prime working ages — especially the age group of 25 to 45—and the loss of a productive member of the household can be particularly devastating to households already living in poverty. HIV / AIDS often affects the utilization... Read More

Acute lymphocytic leukemia and Treatment

Image Acute lymphocytic leukemia and Treatment Journal of Health and Medical Research is a peer review open access journal in field of health and medicine. Here we discuss about acute lymphocytic leukemia and Treatment Acute lymphocytic leukemia (ALL) is a type of cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made. The word "acute" in acute lymphocytic leukemia comes from the fact that the disease progresses rapidly and creates immature blood cells, rather than mature ones. The word "lymphocytic" in acute lymphocytic leukemia refers to the white blood cells called lymphocytes Acute... Read More

Cardiac arrhythmia- Types and Treatment

Image Cardiac arrhythmia- Types and Treatment Journal of Health and Medical Research is a peer review open access journal in field of health and medicine. Here we discuss about Cardiac arrhythmia- Types and Treatment. Heart rhythm problems (heart arrhythmias) occur when the electrical impulses that coordinates your heartbeats don't work properly, causing your heart to beat too fast, too slow or irregularly. Heart arrhythmias (uh-RITH-me-uhs) may feel like a fluttering or racing heart and may be harmless. However, some heart arrhythmias may cause bothersome — sometimes even life-threatening — signs and symptoms. Heart arrhythmia treatment can often control or eliminate fast,... Read More

An EGFR signature predicts cell line and patient sensitivity to multiple tyrosine kinase inhibitors

Image EGFR is an oncogene with a high frequency of activating mutations in non‐small cell lung cancer (NSCLC). EGFR inhibitors have been FDA‐approved for NSCLC and have shown efficacy in patients with certain EGFR mutations. However, only 9‐26% of these patients achieve objective responses. In this study, we developed an EGFR gene signature based on The Cancer Genome Atlas (TCGA) RNA‐seq data of lung adenocarcinoma (LUAD) to direct the preselection of patients for more effective EGFR‐targeted therapy. This signature infers baseline EGFR signaling pathway activity (denoted as EGFR score) in tumor samples, which is associated with tumor sensitivity to EGFR inhibitors and other tyrosine... Read More

Dental stem cells can produce cells which produce milk

Image The ability of adult stem cells to produce various tissue specific populations of cells is of significant importance in the fields of medical and dental science. These cells can replace weakened cells, and are thus a good alternative to traditional tissue regeneration medical therapies. This could also cause whole tissues and organs to develop de novo in the future. Both epithelial cell types of the teeth may be created by dental epithelial stem cells; but it was not yet clear if these cells could also create non-dental cell populations. Researchers in The University of Adelaide brought a new hope for... Read More

The Impact of the COVID-19 Pandemic on Parkinson’s Disease: Hidden Sorrows and Emerging Opportunities

Image In the past few months, the world seems to have come to a virtual standstill. As the SARS-CoV-2 virus continues to spread across the globe, many countries have taken drastic measures to slow down infection rates. These include social distancing, and in some countries a complete lock-down of social and economic life. The impact of the corona virus disease (COVID-19) crisis is evident, on the lives of the worst affected families, our healthcare systems, and the world economy. There are particular concerns around the increased vulnerability of patients living with a chronic disease, and this also includes neurological conditions like... Read More

Expanded Effects of HIV / AIDS Study

Image Human immunodeficiency virus (HIV) is one of the most widely researched viruses in nature, and much remarkable scientific advancement have arisen from developments in HIV / AIDS research, including an in-depth knowledge of viral genetics, pathogenesis and life-saving antiretroviral therapies. HIV is one of history's most intensively researched viruses, contributing to a greater understanding of viral evolution and pathogenesis. In the field of antiretroviral therapy, though, the most remarkable advancements in HIV / AIDS work have arrived. The massive investment in HIV work is adequately explained and confirmed solely on the basis of practical developments pertaining to HIV / AIDS.... Read More

FDA Approves Trodelvy (Sacituzumab govitecan-hziy) for Triple Negative Breast Cancer

Image The US Food and Drug Administration (FDA) approved a new type of therapy for Triple-negative breast cancer that has spread to other parts of the body and hasn’t responded to other treatments. Triple-negative breast cancer is called that because the cancer cells don’t have oestrogen or progesterone receptors and also don’t make too much of the protein called HER2. It has few treatment options and tends to grow and spread faster than other types of breast cancer. Trodelvy (sacituzumab govitecan-hziy) is a type of targeted therapy called an antibody drug conjugate. It works by delivering a chemotherapy drug directly to the cancer... Read More

Fluoride causes dental enamel defects

Image Fluoride is a chemical that occurs naturally and helps avoid cavities by encouraging mineralization and making tooth enamel more acid resistant. For its role in reducing tooth decay, the Centers for Disease Control and Prevention ( CDC) called water fluoridation one of the 20th century's 10 great public health achievements. Dental fluorosis occurs when children between birth and around nine years of age are exposed to elevated levels of fluoride during this crucial period where their teeth develop, which can potentially increase their risk of decay in the tooth. A study revealed that about 25 percent of the surveyed U.S.... Read More

Coordinated strategy to accelerate multiple COVID-19 vaccine candidates is key, NIH experts

Image What A harmonized and collaborative approach to the clinical testing, scale-up and distribution of candidate vaccines to prevent COVID-19 is essential, scientific leaders write in a perspective published today in Science. As the COVID-19 pandemic continues, government, industry and academia have introduced a variety of vaccine candidates. The authors note that more than one effective vaccine approach likely will be required to successfully protect the global community from SARS-CoV-2, the virus that causes COVID-19. They describe a strategic approach to research and development that would generate essential data for multiple vaccine candidates in parallel.   National Institutes of Health Director Francis... Read More

After recovering from COVID-19, are you immune?

Image As coronavirus spreads across the globe, a crucial question has emerged: After recovering from an infection, are people immune? This question is important for understanding who can safely go back to work, as well as for understanding how long the worst impacts of the pandemic are likely to last. Because the virus is so new, the answer isn't fully understood. But so far, scientists say, it looks like SARS-CoV-2 probably induces immunity like other coronaviruses. That means that the human body will probably retain a memory of the virus for at least a few years and should be protected from... Read More

A new way to test the effect of HIV on the brain

Image HIV does not invade nerve cells (neurons) directly, but endangers their work by infecting cells called glia which help and protect neurons. HIV also infects the brain and spinal cord (central nervous system) and induces symptoms such as: anxiety and forgetfulness. AIDS reflects the final stage of HIV infection. A person infected with HIV is diagnosed with AIDS when he or she has a extremely small number of CD4 + T cells and one or more "opportunistic" infections, such as certain forms of pneumonia or tuberculosis, which do not usually affect people with stable immune systems. Even when HIV is... Read More

Parkinson’s disease: no milk today?

Image Several prospective epidemiological studies on large cohorts have consistently reported an association between milk intake and a higher incidence of Parkinson’s disease (PD). Pesticide contaminations of milk and milk’s uprate-lowering effects have been put forward as risk factors to explain epidemiological data. This has led to considerable uncertainty among physicians and avoidance of dairy products by PD patients. However, neither factor stands up to the rational and detailed examination of the literature carried out in this mini-review. We suggest that changes in eating behavior related to pre-motor PD are an alternative potential explanation of correlations observed between milk intake and... Read More

Autophagy in Cancer Therapy

Image Autophagy represents a catabolic program involved in the degradation of cellular components via lysosomes. It serves to mitigate cellular stress and to provide metabolic precursors especially upon starvation. Thereby, autophagy can support the survival of cancer cells. In addition, there is now convincing evidence showing that under certain conditions autophagy can also foster cell death. This dual function of autophagy is also relevant upon anticancer treatment, as many chemotherapeutic agents engage autophagy. A better understanding of the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells will be instrumental to selectively interfere with this cellular program in order... Read More

Link between gum disease and obesity

Image Obesity and gum disease (periodontal) are among the most prevalent non-communicable disorders in the U.S. — and findings indicate that these medical illnesses can be related. This new research investigates the impact of obesity on periodontal non-surgical treatment and assesses possible mechanisms that could explain the link between the two conditions. Researchers find the evidence showed elevated body mass index, waist circumference and body fat ratio to be correlated with an increased risk of contracting gum disease, also known as periodontitis. At one point in time, most experiments evaluated data from population subsets, as opposed to analyzing the same population... Read More

Simple infection control measures could help reduce the spread of Covid-19

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Distinct Role of Striatal Functional Connectivity and Dopaminergic Loss in Parkinson’s Symptoms

Image Degeneration of dopaminergic neurons is a hallmark of Parkinson’s disease. However, its link to Parkinson’s disease symptoms remains unclear. Striatal resting state functional connectivity differentiates between Parkinson’s disease patients and healthy controls and might be a potential mediator of the effects of striatal dopaminergic degeneration onto Parkinson’s disease symptoms. Here, we evaluated the relationship between dopaminergic deficits, striatal functional connectivity (SFC) at rest and different Parkinson’s disease clinical symptoms in the largest currently established cohort of de novo Parkinson’s disease patients. We show that SFC is an independent predictor of symptom severity in Parkinson’s disease in addition to striatal dopaminergic deficits. Furthermore,... Read More

Latest figures on Covid-19 deaths spark fresh calls

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

USP7: Novel Drug Target in Cancer Therapy

Image Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 requires the C-terminal Ub-like domains fold back onto the catalytic domain, allowing the remodelling of the active site to a catalytically competent state by the C-terminal peptide. Until now, numerous proteins have been identified as substrates of USP7, which play a key role in cell cycle, DNA repair, chromatin remodelling, and epigenetic regulation. Aberrant activation or overexpression of USP7 may promote oncogenes is and viral disease, making it a target for therapeutic intervention. Currently, several... Read More

Coronavirus crisis puts vaccine trials on the fast track.

Image The deadly health crisis caused by covid-19 has set off a frenetic race against time to develop a vaccine, with progress being made way faster than any previous effort. While 83 companies across the globe are vying to develop a vaccine, six have already advanced to human trials or clinical evaluation stage, with 77 in pre-clinical evaluation phase as on 23 April, according to the World Health Organization (WHO) database That’s an unprecedented pace. The mumps vaccine—the fastest to ever reach the markets—took four years to licensing in 1967, according to National Geographic. Zydus Cadila, Serum Institute of... Read More

Combination prevention for COVID-19

Image The coronavirus disease 2019 (COVID-19) pandemic has produced the fear and disorder inevitably provoked by emerging pathogens. As such, it should also inspire consideration of our experience with HIV over the past 40 years. As with HIV, the road to reducing infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the cause of COVID-19), and attendant morbidity and mortality, requires medical and nonmedical strategies. The most important lesson learned from tackling HIV is to use a combination of prevention strategies. The first step to stopping the spread of SARS-CoV-2 has already been taken—behavioral changes. This reflects a rapid but imperfect... Read More

New HIV vaccine could identify and destroy latent virus

Image Antiretroviral therapy may quickly become ineffective, as scientists have successfully used immune cells to push and kill the latent form of HIV from its hiding spot. The findings could quickly lead to a vaccine against HIV. With the help of antiretroviral therapy, over half of these people now have a very low level of the virus. This means that they can no longer trasmit it to other people. Antiretroviral therapy can keep HIV in check so well that the virus is near-undetectable in the blood. The principal site of the attack is the immune system, in particular the CD4 T-lymphocytes... Read More

Teeth act as 'life history'

Image Teeth are a lasting and faithful biological record of the entire life of the organism, from the creation of the dent to death, a team of researchers found. Her research offers new evidence of the effect events have on an organism, such as reproduction and incarceration. The research focused on cementum, the dental tissue that covers the tooth's root. It begins to form annual layers -- similar to a tree's "rings" -- from the time the tooth surfaces in the mouth. The finding of this little-studied tissue that personal aspects of a person's life are documented promises to put cement... Read More

Pancreatitis || Complications and Treatment

Image Pancreatitis || Complications and Treatment Journal of Health and Medical Research is a peer review open access journal in field of health and medicine. Here we discuss about Pancreatitis. Pancreatitis is inflammation in the pancreas. The pancreas is a long, flat gland that sits tucked behind the stomach in the upper abdomen. The pancreas produces enzymes that help digestion and hormones that help regulate the way your body processes sugar (glucose). Pancreatitis can occur as acute pancreatitis — meaning it appears suddenly and lasts for days. Or pancreatitis can occur as chronic pancreatitis, which is pancreatitis that occurs over many... Read More

Acute kidney failure || Complications and Prevention

Image Acute kidney failure || Complications and Prevention Acute kidney failure occurs when your kidneys suddenly become unable to filter waste products from your blood. When your kidneys lose their filtering ability, dangerous levels of wastes may accumulate, and your blood's chemical makeup may get out of balance. Acute kidney failure — also called acute renal failure or acute kidney injury — develops rapidly, usually in less than a few days. Acute kidney failure is most common in people who are already hospitalized, particularly in critically ill people who need intensive care. Acute kidney failure can be fatal and requires intensive... Read More

Current Scenario of HIV/AIDS

Image Acquired immune deficiency syndrome (AIDS) is a chronic condition caused by the HIV virus. HIV infection is a very real threat and can simply be considered a plague on mankind. HIV-1 was identified as the causative organism soon after the first official recognition of HIV patients in the USA. HIV-2 was reported first in Africa in 1985 and is markedly different from HIV-1. Since its discovery, the global prevalence of HIV has grown and has now spread around the globe, following advancements in antiretroviral therapies (ART). The mortality and morbidity levels associated with HIV infections in developed countries remain high... Read More

Tetanus, diphtheria and pertussis (DPT) vaccine

Image Tetanus, diphtheria and pertussis (DPT) vaccine Journal of Health and Medical Research is a peer review open access journal in field of health and medicine. Here we discuss about DPT Vaccine. Tetanus, diphtheria and pertussis are very serious diseases. Tdap vaccine can protect us from these diseases. And, Tdap vaccine given to pregnant women can protect newborn babies against pertussis. TETANUS (Lockjaw) is rare in the United States today. It causes painful muscle tightening and stiffness, usually all over the body. It can lead to tightening of muscles in the head and neck so you can't open your mouth, swallow, or... Read More

Congestive Heart Failure: Types, Causes and Treatment

Image Congestive Heart Failure: Types, Causes  and Treatment Journal of Health and Medical Research is a peer review open access journal in field of health and medicine. Here we discuss about Congestive Heart Failure Congestive heart failure (CHF) is a chronic progressive condition that affects the pumping power of your heart muscles. While often referred to simply as “heart failure,” CHF specifically refers to the stage in which fluid builds up around the heart and causes it to pump inefficiently. You have four heart chambers. The upper half of your heart has two atria, and the lower half of your heart has... Read More

Sex Differences and Bone Metastases of Breast, Lung, and Prostate Cancers: Do Bone Homing Cancers Favor Feminized Bone Marrow?

Image Sex-associated differences in bone metastasis formation from breast, lung, and prostate cancer exist in clinical studies, but have not been systematically reviewed. Differences in the bone marrow niche can be attributed to sexual dimorphism, to genetic variations that affect sex hormone levels, or to the direct effects of sex hormones, natural or exogenously delivered. This review describes the present understanding of sex-associated and sex hormone level differences in the marrow niche and in formation of bone metastasis during the transition of these three cancers from treatable disease to an often untreatable, lethal metastatic one. Our purpose is to provide insight... Read More

Bone Marrow Adipose Tissue: A New Player in Cancer Metastasis to Bone

Image The bone marrow is a favoured site for a number of cancers, including the haematological malignancy multiple myeloma, and metastasis of breast and prostate cancer. This specialized microenvironment is highly supportive, not only for tumour growth and survival but also for the development of an associated destructive cancer-induced bone disease. The interactions between tumour cells, osteoclasts and osteoblasts are well documented. By contrast, despite occupying a significant proportion of the bone marrow, the importance of bone marrow adipose tissue is only just emerging. The ability of bone marrow adipocytes to regulate skeletal biology and haematopoiesis, combined with their metabolic activity,... Read More

Brush your teeth to shield your heart

Image Past evidence shows inadequate oral hygiene contributes to bacteria in the blood, allowing the body to become inflamed. Inflammation raises the risk of atrial fibrillation (irregular heartbeat) and cardiac failure (impairment of the capacity of the cardiac to pump blood or relax and fill with oxygen). Tooth brushing was associated three or more times a day with a 10 percent lower risk of atrial fibrillation and a 12 percent lower risk of heart failure over 10.5 years of follow-up. The results were independent of a variety of variables including age, class, socioeconomic status, daily exercise, alcohol intake, body mass index... Read More

Steps towards an HIV vaccine

Image Historically the safest method for preventing people from infectious diseases has been vaccine. Although there are many strategies for HIV prevention, the production of a safe and reliable HIV vaccine remains crucial to putting a permanent end to the HIV / AIDS pandemic. NIAID and its strategic collaborators pursue various research initiatives aimed at identifying candidates for next generation vaccines. When exposed to an invading virus, the human immune system develops proteins called antibodies that become specialized to recognize and prevent infection by that particular virus. Thousands of strains of HIV-1 have been identified, and each can rapidly mutate to... Read More

Frequency and neural correlates of pauses in patients with formal thought disorder

Image Formal thought disorder (FTD) is manifest clinically as incoherent speech and is a central feature of schizophrenia. Thought disordered speech appears disorganized and lacks a clear theme or goal, suggesting that impairment in speech planning might be a key underlying factor. Coherent discourse also entails the continuous monitoring and editing of the verbal output, such that the intended and articulated speech correspond. The articulation of unusual or inappropriate words and the introduction of incongruous topics in thought disordered speech are thought to reflect a deficit in verbal self-monitoring in schizophrenia. Although normal discourse involves speech that is described as... Read More

On the relation of psychiatric disorder and neural defect

Image The debate about the relation between psychiatric disorder and neural defect has produced different argumentative strategies for and against the identification of these two phenomena. I'll coin these strategies as an ontological strategy, an extensional strategy, and an intensional strategy, on which I will focus in this article. The first, ontological strategy takes the long road over a detailed characterization of the nature of psychiatric disorders and of neural defects. It then goes on to argue for a relation between these two ontological kinds. One anti-reductionist proposition of an ontological strategy can be found in Stir. He provides a... Read More

Nursing response to the Coronavirus crisis

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Nursing Times survey reveals negative impact of Covid-19 on nurse mental health

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Coronavirus Vaccine Update: UK's Oxford University begins coronavirus vaccine trial, Germany close behind

Image Coronavirus Vaccine Latest Update: Oxford University in the United Kingdom has begun the much-awaited coronavirus vaccine trial on humans. The first two volunteers were injected with the vaccine on April 23, 2020. Germany has also approved the nation's first clinical trials of the coronavirus vaccine on human volunteers. Germany's medical regulatory body, the Paul Ehrlich Institute (PEI) approved the nation's first clinical trials on humans on April 22, 2020. The potential coronavirus vaccine has been developed by German firm Biontech and US giant Pfizer. The UK and German coronavirus vaccine trials on humans are among the only five clinical trials... Read More

A New Future - Tooth Bioengineered

Image Recent advancement in stem-cell regenerative bioengineering therapy allows bioengineered tooth buds to be acquired for laboratory animals, and would certainly be a better, effective, clinically applicable tooth replacement treatment. Tooth loss is a global health concern that actually impacts millions of people worldwide. It affects not only mastication and pronunciation but also a number of physiological and psychological issues. The new quality gold procedure for removing the tooth is dental implants. Bioengineered tooth is one of the regenerative products where tissue engineering is carried out using stem cells. Stem cells are defined as clonogenic cells capable of both self-renewal and... Read More

Current and future priorities in developing optimal HIV medicines

Image Since zidovudine monotherapy was approved for AIDS diagnosis in 1987, significant progress has been made in designing antiretroviral drugs that are more effective against HIV infection. The quality of care changed from less effective and potentially toxic mono- and dual treatments used in the early 1990s to increasingly successful and well tolerated mixed drug regimens, including the introduction of fixed-dose combos (FDCs), and the harmonization of treatment regimens between specific groups. In the last three decades, at least 30 individuals and more than 20 dual and triple combined antiretroviral (ARV) medications were approved for treatment, and one dual combination for... Read More

Coronavirus vaccine could be ready sooner than expected: Health group

Image A vaccine to halt the coronavirus pandemic could be available as early as this year for vulnerable groups such as health-care workers, even faster than initially thought, according to a key group at the heart of the global development effort. The Coalition for Epidemic Preparedness Innovations, which is funding nine different coronavirus vaccine projects, has previously suggested a shot could be ready within 12 to 18 months, an already ambitious target. That assessment didn’t account for the possibility of companies working closely together to accelerate the process, faster enrollment in human trials and other factors, according to Richard Hatchett, the... Read More

Japanese encephalitis vaccine

Image Japanese encephalitis vaccine Journal of Health and Medical Research is a peer review open access journal in field of health and medicine. Here we discuss about Japanese encephalitis. Japanese encephalitis (JE) is an infection of the brain caused by the Japanese encephalitis virus (JEV). While most infections result in little or no symptoms, occasional inflammation of the brain occurs. In these cases, symptoms may include headache, vomiting, fever, confusion and seizures. This occurs about 5 to 15 days after infection. JEV is generally spread by mosquitoes, specifically those of the Culex type. Pigs and wild birds serve as a reservoir for the virus. The disease mostly occurs outside of... Read More

Migraine in Malaysian Population: A Cause for Alarm

Image Migraine in Malaysian Population: A Cause for Alarm Journal of Health and Medical Research is a peer review open access journal in field of health and medicine. Migraine in Malaysian Population: A Cause for Alarm is an opinion article which was published in volume 1, issue 1 of our journal. Headache is the most common disorder of the nervous system, comprising of a number of categories. Migraine is one of the crucial sub-types among them, to be precise. However, compared to the other types, migraine is inexplicably diverse in its manifestations, at the same time, extremely misinterpreting, under-diagnosed and more... Read More

Advances in Dental Materials

Image The dental sciences started in ancient Egypt thousands of years ago, using valuable materials such as gold for restorations. Around the time new technologies were being used as new forms of treatment emerged in dentistry. Additionally, emerging innovations help dentists develop innovative methods for diagnosis. Rigid polymers, elastomers, metals, alloys, ceramics, inorganic salts and composite materials are commonly used within a variety of dental materials Dental materials are known as the foundation of both oral and dental scientific developments. In addition, as a first step before industrial use, computational simulation and stress analysis of the restorative components, prosthesis, and modern... Read More

miRNAs in the Diagnosis and Prognosis of Skin Cancer

Image Skin cancer is, at present, the most common type of malignancy in the Caucasian population. Its incidence has increased rapidly in the last decade for both melanoma and non-melanoma skin cancer. Differential expression profiles of microRNAs (miRNAs) have been reported for a variety of different cancers, including skin cancers. Since miRNAs’ discovery as regulators of gene expression, their importance grew in the field of oncology. miRNAs can post-transcriptionally regulate gene expression, tumour initiation, development progression, and aggressiveness. Nowadays, these short regulatory RNAs are perceived as one of the epigenetic markers for the identification of new diagnostic and/or prognostic molecular markers.... Read More

A rising cancer prevention target of RSK2 in human skin cancer

Image RSK2 is a p90 ribosomal S6 kinase family (p90RSK) member regulating cell proliferation and transformation induced by tumour promoters such as epithelial growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate. This family of p90RSK has classified as a serine/threonine kinase that respond to many growth factors, peptide hormones, neurotransmitters, and environmental stresses such as ultraviolet (UV) light. Our recent study demonstrates that RSK2 plays a key role in human skin cancer development. Activation of RSK2 by EGF and UV through extracellular-activated protein kinases signalling pathway induces cell cycle progression, cell proliferation, and anchorage-independent cell transformation. Moreover, knockdown of RSK2 by si-RNA or sh-RNA abrogates... Read More

Migraine and stroke: “vascular” comorbidity

Image Several comorbidities are associated to migraine. Recent meta-analyses have consistently demonstrated a relationship between migraine and stroke, which is well-defined for ischemic stroke and migraine with aura (MA), even stronger in females on oral contraceptives or smokers. However, there seems to be no clear-cut association between stroke in migraines and the common vascular risk factors, at least in the young adult population. Migraines also run an increased risk of haemorrhagic stroke, while the association between migraine and cardiovascular disease remains poorly defined. Another aspect is the relationship between migraine and the presence of silent brain lesions. It has been demonstrated... Read More

The Chronic Migraine Brain: What Have We Learned From Neuroimaging?

Image Chronic migraine is a highly disabling disease with a great impact on socioeconomic functioning and quality of life of migraine patients. Chronic migraine usually evolves from episodic migraine that gradually increases in attack frequency, supporting the view of migraine as a spectrum disorder. Pathophysiological mechanisms responsible for migraine cornification are not fully understood. Likewise episodic migraine, chronic migraine patients show widespread functional and structural alterations of cortical and subcortical pain-related brain areas. However, chronic migraine patients experience a more pronounced dysfunction of the pain inhibitory network and an increased sensitization of the central pain pathways, which might explain the higher... Read More

Impact of coronavirus in nursing care system

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

COVID-19 vaccine protects monkeys from new coronavirus, Chinese biotech reports

Image For the first time, one of the many COVID-19 vaccines in development has protected an animal, rhesus macaques, from infection by the new coronavirus, scientists report. The vaccine, an old-fashioned formulation consisting of a chemically inactivated version of the virus, produced no obvious side effects in the monkeys, and human trials began on 16 April. Researchers from Sinovac Biotech, a privately held Beijing-based company, gave two different doses of their COVID-19 vaccine to a total of eight rhesus macaque monkeys. Three weeks later, the group introduced SARS-CoV-2, the virus that causes COVID-19, into the monkeys’ lungs through tubes down their tracheas, and none... Read More

Exhaustion of B-cell in HIV infection

Image HIV-associated B-cell exhaustion was first identified in 2008, shortly after the presentation of recurrent virus-induced T-cell exhaustion, and the discovery of a subset of B cells in tonsil tissues with immune-regulatory features close to those found in T-cell exhaustions. HIV infection immunopathogenesis entails disruptions of both innate and adaptive immunity including B cells and the antibodies they produce. Persistent HIV replication is often associated with other B-cell disruptions including over-representation of active and depleted B-cell memory subsets, the latter being the most prevalent characteristic during the chronic infection period. In addition to the presence of additional memory B-cell subsets, which... Read More

Effectiveness of Sensitive Paste with Natural Extract

Image The sensitivity of the tooth also called as Dentin Hypersensitivity, the hypersensitivity of the dentin is not a personal concern and is easily rectified by the standard oral hygiene process. Dentin hypersensitivity is not pathological defects associated with teeth, it is medically described as a painful reaction to thermal, chemical, mechanical or osmotic stimulant treatment applied to opened dentinal tubules. Dentinal tubules are responsible and play a crucial role in Dentin hypersensitivity; it helps to transfer the stimulant and irritant potential up to the pulp. Blocking of dentinal tubules and reduce the diameter of dentinal tubules are helpful to get... Read More

Home nursing services/care

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Two coronavirus vaccine candidates enter human trials, 60 in pre-clinical stage: WHO

Image Two candidate vaccines for COVID-19 have entered the first phase of human clinical trials and another 60 candidate vaccines are in pre-clinical studies, the World Health Organisation (WHO) has confirmed. The vaccine candidate jointly developed by CanSino Biological Inc and Beijing Institute of Biotechnology uses the non-replicating viral vector as the platform, same as the non-corona candidates like Ebola, to develop a vaccine with a 'Adenovirus Type 5' candidate, a draft landscape of COVID-19 vaccine candidates brought out today. Sources say adenoviruses are common viruses that cause pneumonia and can deliver potential antigens to stimulate the production of antibodies that... Read More

HIV-2 as a guide for finding a safe treatment for HIV

Image There are two types of HIV viruses: HIV-1 is pandemic and violent, while HIV-2 is mainly restricted to West Africa, and less pathogenic. HIV-2 was first detected in West Africa in 1986. Concepts of effective vaccines and therapies aimed at reducing the progression of HIV disease and spreading it by sustained regulation of viral replication without lifelong treatment were proposed as more realistic options for regulation of the HIV pandemic. Many studies also suggested that if a normal course of disease occurs, only about 15–25 percent of HIV-2 infected individuals will progress to AIDS. Such findings, however, were focused on data... Read More

Helicobacter pylori -Peptic ulcers

Image Helicobacter pylori -Peptic ulcers H. pylori is a common type of bacteria that grows in the digestive tract and has a tendency to attack the stomach lining. It infects the stomachs of roughly 60 percent. Trusted Source of the world’s adult population. H. pylori infections are usually harmless, but they’re responsible for the majority of ulcers in the stomach and small intestine. The “H” in the name is short for Helicobacter. “Helico” means spiral, which indicates that the bacteria are spiral shaped. H. pylori often infect your stomach during childhood. While infections with this strain of bacteria typically don’t cause... Read More

Measles Virus| Vaccination

Image Measles Virus| Vaccination Journal of Health and Medical Research is an open access peer reviewed journal. We would like to discuss about Measles in this note. Measles is a childhood infection caused by a virus. Once quite common, measles can now almost always be prevented with a vaccine. Also called rubeola, measles can be serious and even fatal for small children. While death rates have been falling worldwide as more children receive the measles vaccine, the disease still kills more than 100,000 people a year, most under the age of 5. As a result of high vaccination rates in general,... Read More

Neurological Diseases with Autism Spectrum Disorder: Role of ASD Risk Genes

Image Autism spectrum disorder (ASD) is frequently comorbid with other neurological disorders such as intellectual disability (ID) or global development delay (GDD) and epilepsy. The pathogenesis of ASD is complex. So far, studies have identified more than 1000 ASD risk genes. Most of them were also reported to relate with other neurological diseases, and only several of them have been confirmed as pathogenic genes for autism. Little is known about the roles of these risk genes in neurological diseases with ASD. In the present study, we recruited a cohort of 158 neurological disorder propends with 163 variants of 48 ASD risk... Read More

Protective effects of ginseng on neurological disorders

Image Ginseng (Order: Appeals, Family: Araliaceae, Genus: Panax) has been used as a traditional herbal medicine for over 2000 years, and is recorded to have antianxiety, antidepressant and cognition enhancing properties. The protective effects of ginseng on neurological disorders are discussed in this review. Ginseng species and ginsenosides, and their intestinal metabolism and bioavailability are briefly introduced. This is followed by molecular mechanisms of effects of ginseng on the brain, including glutamatergic transmission, monoamine transmission, oestrogen signalling, nitric oxide (NO) production, the Keap1/Nrf2 adaptive cellular stress pathway, neuronal survival, apoptosis, neural stem cells and neuroregeneration, microglia, astrocytes, oligodendrocytes and cerebral micro... Read More

HIV-1 Neutralization Tiers

Image HIV-1 isolates are also classified using 'rank' phenotype neutralization. Tier classification has significant implications for controlling and understanding vaccine-induced responses to neutralizing antibodies. Identifying HIV-1 vaccines which generate broadly neutralizing antibodies (bNAbs) will require reliable information on the ability of vaccine-induced antibodies to neutralize various virus strains. Tier 1A is the most sensitive neutralization phenotype and represents a very minor fraction of circulating strains. Tier 1B is the next most sensitive and represents a larger but still relatively small fraction of circulating strains. For several years, T-cell line-adapted strains were the primary source of vaccine immunogens and were highly susceptible... Read More

Genetic Alterations of TRAF Proteins in Human Cancers

Image The tumour necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic adaptor proteins regulate the signal transduction pathways of a variety of receptors, including the TNF-R superfamily, Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-I-like receptors (RLRs), and cytokine receptors. TRAF-dependent signalling pathways participate in a diverse array of important cellular processes, including the survival, proliferation, differentiation, and activation of different cell types. Many of these TRAF-dependent signaling pathways have been implicated in cancer pathogenesis. Here we analyse the current evidence of genetic alterations of TRAF molecules available from The Cancer Genome Atlas (TCGA) and the Catalog of Somatic Mutations in... Read More

Does Cancer of Unknown Primary (CUP) Truly Exist as a Distinct Cancer Entity?

Image Cancer of unknown primary (CUP) designates an enigmatic cancer entity with histologic confirmation of malignancy from a metastasis but no identifiable primary tumour in spite of a thorough diagnostic work-up. In this review, we discuss the validity of CUP as a distinct cancer entity as well as diagnostic pitfalls. As arguments against a distinct entity, the diagnosis of CUP is erroneous in some cases. Diagnostic pitfalls include incomplete diagnostics, uncertainty in classifying a lesion as either primary or metastasis and mistaking a relapse of an antecedent malignancy as CUP due to histologic and immunohistologic disparities. Given the high frequency of... Read More

Recent Developments in Dental Software

Image With more technological advances, the dental industry continues to develop and expand which will improve the patient experience. Dentists, researchers and scientists continue to look with minimally invasive methods for ways of improving dental health.Dental software is used to process payments, to maintain records and to plan them. There is a variety of management tools for dental practice which are software systems or frameworks. Computer apps are others, and cloud-based systems are others. People who develop these programs or know how to use them while working in dental clinics have valuable skills which are highly valued in the dental sector.... Read More

Novel SARS-CoV-2 coronavirus

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Bacille Calmette-Guérin (BCG) vaccination and COVID-19

Image There is no evidence that the Bacille Calmette-Guérin vaccine (BCG) protects people against infection with COVID-19 virus. Two clinical trials addressing this question are underway, and WHO will evaluate the evidence when it is available. In the absence of evidence, WHO does not recommend BCG vaccination for the prevention of COVID-19. WHO continues to recommend neonatal BCG vaccination in countries or settings with a high incidence of tuberculosis.1 There is experimental evidence from both animal and human studies that the BCG vaccine has non-specific effects on the immune system. These effects have not been well characterized and their clinical relevance... Read More

Study finds remdesivir effective against a key enzyme of coronavirus that cause COVID-19

Image Summary: Scientists have shown that the drug remdesivir is highly effective in stopping the replication mechanism of the coronavirus that causes COVID-19. The finding follows closely on research demonstrating how the drug worked against the Middle East Respiratory Syndrome (MERS) virus, a related coronavirus. Scientists at the University of Alberta have shown that the drug remdesivir is highly effective in stopping the replication mechanism of the coronavirus that causes COVID-19, according to new research published today in the Journal of Biological Chemistry. The paper follows closely on research published by the same lab in late February that demonstrated how the... Read More

HIV testing itself and the global presence of undiagnosed persons

Image HIV self-testing (HIVST) has grown rapidly in recent years and is now considered to be a modern and vital tool for managing the epidemic. Self-testing for HIV involves collection of saliva or a finger stick blood sample by an individual, either in a supervised or unsupervised setting, for analysis by a laboratory or, more recently, for analysis by the user – much like a home pregnancy test. In general, individuals complete testing with little or no training. A study in Seattle, WA, USA, randomized MSM to access to self-tests versus standard clinical tests and followed participants for a median of... Read More

Recent trends in Plastic Surgery 2020 (Awards)

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Chlorhexidine mouthwash effects on oral microbiome

Image Chlorhexidine has been widely used as an antiseptic agent in dental practice since 1970, owing to its long-lasting antibacterial efficacy with a wide range of action. In several studies using in vitro methods documenting positive results of CHX in reducing the proliferation of bacterial species associated with parodontal disease, such as Enterobacteria, Porphyromonas gingivalis, Fusobacterium nucleatum and various Actinomyces and Streptococcus species, including Streptococcus mutans, which are known to be the major etiological agent of dental caries. The use of CHX was effective in the treatment of halitosis, especially in reducing the levels of halitosis-related bacteria colonising the dorsal surface... Read More

Optical imaging technology may help surgeons better treat cancer, brain diseases

Image Optical imaging technology may help surgeons better treat cancer, brain diseases Journal of Health and Medical Research is an open access peer reviewed journal. Journal of Health and Medical Research publishes articles covering wide range of disciplines including Biochemistry, Pharmacology and Toxicology focused on developing effective medicines, efficient procedures dealing both preclinical aspects like molecular and cellular research, in vitro and animal model studies as well as clinical trials A new tool for medical professionals may help shed more light on tumors in the body and how the brain operates. Purdue University researchers created technology that uses optical imaging to better... Read More

Recent Trends of Common Factors of Geriatric Medicine and Rehabilitation Medicine

Image Recent Trends of Common Factors of Geriatric Medicine and Rehabilitation Medicine   Journal of Health and Medical Research publishes articles covering wide range of disciplines including Biochemistry, Pharmacology and Toxicology focused on developing effective medicines, efficient procedures dealing both preclinical aspects like molecular and cellular research, in vitro and animal model studies as well as clinical trials. Health research topics relating to disease prevalence, risk factors, public health intervention outcomes as well as healthcare economics and medical research topics including etiology of disease, prognosis, management and treatment, functional aspects of human physiology, mechanisms of health improvement and reduction in the burden... Read More

Use of Primary Care Datasets for High Risk and Early Cancer Detection

Image   In 2018, there were 17 million new cases of cancer worldwide. For most patients, entry into the health system occurred through primary care following symptomatic presentation at general practice. In most countries, general practitioners (GPs) act as ‘’gatekeepers” to secondary health services and specialist care, assessing risk and ensuring appropriate and timely movement of patients from primary to secondary care. Based on the presenting problem or patient needs, GPs can pursue a range of actions, from issuing prescriptions, undertaking further investigations such as pathology, radiology or imaging services and referral to specialist care services. General practice can therefore make... Read More

Music, Brain, and Rehabilitation: Emerging Therapeutic Applications and Potential Neural Mechanisms

Image Music is an important source of enjoyment, learning, and well-being in life as well as a rich, powerful, and versatile stimulus for the brain. With the advance of modern neuroimaging techniques during the past decades, we are now beginning to understand better what goes on in the healthy brain when we hear, play, think, and feel music and how the structure and function of the brain can change as a result of musical training and expertise. For more than a century, music has also been studied in the field of neurology where the focus has mostly been on musical deficits... Read More

Women Oncology 2020

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Journal of Pharmaceutical Sciences and Drug Development: An open access peer-reviewed Journal | Volume 2 Issue 1

Image Journal of Pharmaceutical Sciences and Drug Development (JPSDD) is an open access, peer-reviewed journal that focuses on all aspects of Pharmaceutical Sciences. Celebrating a successful publication history, JPSDD solicits research contributions pertaining to drug design, drug discovery, natural products, formulation, personalized medicine, testing the efficacy of drug molecule in vitro and in vivo, pharmacokinetics, pharmacogenomics, analytical sciences, nanotechnology, therapeutic aspects, quality control, optimization by medicinal chemistry, drug pharmacodynamics, evaluation of safety and toxicity of drug molecules, regulatory science as well as computational approaches. The Editorial Board of Journal of Pharmaceutical Sciences and Drug Development is overwhelmed by... Read More

Journal of Pharmaceutical Sciences and Drug Development | Upcoming Issue

Image Journal of Pharmaceutical Sciences and Drug Development solicits research contributions pertaining to drug design, drug discovery, natural products, formulation, personalized medicine, testing the efficacy of drug molecule in vitro and in vivo, pharmacokinetics, pharmacogenomics, analytical sciences, nanotechnology, therapeutic aspects, quality control, optimization by medicinal chemistry, drug pharmacodynamics, evaluation of safety and toxicity of drug molecules, regulatory science as well as computational approaches. Editor-in-Chief David Gortler is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.... Read More

Natural history of HIV infection

Image Information about the natural history of HIV quickly accrued in the early days of the HIV epidemic. But the widespread use of effective antiretroviral therapy (ART) has caused a shift in the research community's emphasis away from natural history studies to those of treated infection. Nonetheless, our understanding of natural history has seen many developments in recent years. In the absence of Medicine, the normal course of untreated HIV infection differs widely with certain HIV-positive individuals who are able to maintain elevated CD4 cell counts and/or suppressed viral load. Although there is increasing evidence that initiation of ART during primary... Read More

Inflammation and cancer risk: an evaluation of biomarker profiles

Image   Several recent reports have provided data that cancer development is substantially controlled by the immune system, and that immunotherapy may be a credible strategy in cancer. Chronic inflammatory conditions such as reflux esophagitis (oesophageal cancer), inflammatory bowel disease and chronic ulcerative colitis (colorectal cancer), chronic pancreatitis (pancreatic cancer), asbestosis (lung cancer), as well as infections like hepatitis (hepatocellular cancer) and mononucleosis (Burkett’s Lymphoma) have been linked to carcinogenesis. However, the use of inflammatory biomarkers as early predictive markers has been disappointing. For instance, studies evaluating the associations of C-reactive protein, a commonly used inflammation-related biomarker, with colorectal cancer (CRC)... Read More

Advances in CNS Repair, Regeneration, and Neuroplasticity: From Basic Mechanisms to Therapeutic Strategies

Image   The pathophysiology of CNS lesions is very complicated, including secondary damages to neural tissues after a primary injury, neuronal and glial loss, scar formation, and permanent disconnections of axonal tracts around the lesion. Loss of neural cells and networks in the CNS often causes persistent functional deficits with very limited recovery. Currently, there are few treatments for patients suffering from neurological functional deficits. Recent advances in understanding the secondary injury mechanism and signalling pathways for controlling CNS regeneration may help develop novel and effective neuroprotective and regenerative strategies. However, our understanding of the molecular and cellular mechanisms for CNS... Read More

Impact of Tooth Fluorosis over a time in adults

Image Dental fluorosis is characterized as the hypomineralization of tooth enamel resulting from chronic, excessive fluoride ingestion during the development of the tooth, particularly during the pre-eruptive maturation period. Most cases of fluorosis are moderate, and treatment is not required. For more serious situations, teeth whitening, veneers, or other methods of cosmetic dentistry may be used to remedy any lasting discolouration. They no longer risk developing fluorosis once a child reaches the age of 8. Where dental fluorosis occurs in the primary teeth, the gingival third of the second primary molars is the most commonly seen. In general, the growth of... Read More

Pediatrics and Primary Care- Pediatrics Care

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

The age of future dentistry: recent developments in restorative dentistry and future prospects

Image As the year is passing, many new inventions are occurring in the field of dental and day by day people are also starting using the new products and mechanism for the treatment of dental problems. Through dentistry the main aim is to provide patients with the best dental treatment. It can also be done with the aid of a trained dental professional and their staff. Science is witnessing great changes every day which are moving mankind into a new age of dentistry. Clinicians with decades of knowledge or the dental history student should look back at the advances in dentistry... Read More

Designing New HIV Infection Inhibitors

Image The gp120 protein in the HIV envelope initially makes contact with CD4, a protein receptor on the target cell surface, in order to infect cells. This first interaction with CD4 allows the viral protein gp120 to change its shape — facilitating the virus 'entry into the cell. There are currently two FDA-approved drugs that can block this process — Maraviroc and Enfuvirtide — and the same class (entry inhibitors) search for more drugs continue. The researchers investigated MF275's ability to prevent infection by various HIV strains. In some cases the medication effectively blocked entry. However, in others the drug has... Read More

Discovery of new biomarker in blood could lead to early test for Alzheimer's disease

Image Discovery of new biomarker in blood could lead to early test for Alzheimer's disease Researchers at the University of California San Diego discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker for early detection of Alzheimer's disease. The work could lead to the development of a blood test to identify individuals who will develop the disease years before they show symptoms. The PHGDH gene produces RNA and proteins that are critical for brain development and function in infants, children and adolescents. As people get older, the gene typically ramps down its production... Read More

Dental Phenotypes in Van der Woude Syndrome

Image Dental Phenotypes in Van der Woude Syndrome Journal of Health and Medical Research provides a global platform for facilitating and promoting health and medical research communications, exchange of research concepts, sharing of recent developments, observations, expert opinions and innovative concepts as well as coordinated scientific programs. With open accessibility, the journal aims to provide inspiration to the students, interns and young medical professionals in their research careers. Van der Woude Syndrome (VWS) consists of a genetic abnormality attributed to mutations in the IRF6 gene, characterized by the presence of paramedian pits in the lower lip, cleft lip and/or palate and hypodontia.... Read More

Conference on Nursing Science and Practice

Image Conference on Nursing Science and Practice Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at... Read More

Nursing Care Plans: Nursing Care

Image Nursing Care Plans: Nursing Care Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special... Read More

Effect of Exercises Training on Fatigue, Depression and Physical Activity in Patients with Systemic Lupus Erythematosus

Image Effect of Exercises Training on Fatigue, Depression and Physical Activity in Patients with Systemic Lupus Erythematosus Journal of Health and Medical Research is an open access peer reviewed journal which provides a global platform for facilitating and promoting health and medical research communications, exchange of research concepts, sharing of recent developments, observations, expert opinions and innovative concepts as well as coordinated scientific programs. With open accessibility, the journal aims to provide inspiration to the students, interns and young medical professionals in their research careers. It publishes articles covering wide range of disciplines including Biochemistry, Pharmacology and Toxicology focused on developing effective... Read More

Reformulation-Focused Life Cycle Management of the FDA-Approved Drugs

Image Reformulation-Focused Life Cycle Management of the FDA-Approved Drugs Journal of Health and Medical Research provides a global platform for facilitating and promoting health and medical research communications, exchange of research concepts, sharing of recent developments, observations, expert opinions and innovative concepts as well as coordinated scientific programs. With open accessibility, the journal aims to provide inspiration to the students, interns and young medical professionals in their research careers. Scope of the Journal Journal of Health and Medical Research publishes articles covering wide range of disciplines including Biochemistry, Pharmacology and Toxicology focused on developing effective medicines, efficient procedures dealing both preclinical aspects like... Read More

Patients’ Satisfaction and Associated Factors towards Nursing Care

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Sandwich Generation

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Priorities for the development of optimal HIV drugs in Current time and future

Image The Global Antiretroviral (ARV) optimization project initially focused on increasing global access to key ARV drugs available at the time by lowering costs and simplifying manufacturing processes, seeking to achieve rapid reduction in HIV mortality, life survival and AID progression prevention, and the risk of transmission of HIV in the local region. With the emerging science of HIV treatment in the last decade, new measures have been taken to ensure a shift to new drugs and formulations with improved efficacy, lower toxicity, fewer contraindications and higher resilience against drug resistance, to reduce the need to turn to more complicated and... Read More

WHO launch trial testing 4 potential COVID-19 treatments

Image The World Health Organization (WHO) have launched SOLIDARITY, a giant trial, testing the potential of therapies, old and new, to beat the coronavirus that is causing the current pandemic.. In a press briefing last Friday, WHO director-general, Dr. Tedros Adhanom Ghebreyesus, announced the launch of SOLIDARITY, a giant multinational trial for testing therapies that researchers have suggested may be effective against COVID-19. “That’s why WHO [have] launched the SOLIDARITY trial, to generate robust, high quality evidence as fast as possible,” Dr. Ghebreyesus said.  Repurposing an experimental Ebola drug Scientists originally developed remdesivir as... Read More

Flu drug used in Japan shows promise in treating COVID-19

Image A drug used in Japan to treat influenza seems to be effective at treating the novel coronavirus that causes COVID-19, according to news reports. The antiviral drug, called Favipiravir or Avigan, showed positive outcomes in clinical trials involving 340 individuals in Wuhan and Shenzhen, said Zhang Xinmin, of China's science and technology ministry, The Guardian reported. "It has a high degree of safety and is clearly effective in treatment," Zhang said Tuesday (March 17), The Guardian reported. Developed by Fujifilm Toyama Chemical, the antiviral drug is being... Read More

Organ Preservation in Treatment of Head and Neck Cancers

Image Organ preservation with acceptable late functional outcome is becoming the most favourable goal in head and neck cancer treatment since awareness of “coming back to life”-needs of survivors increased. Patient age dropped down especially in ororpharynx cancer in the last years mainly due to HPV. Growing literature regarding rehabilitation, late functional outcome and toxicity is focusing this issue strongly and pushing all in head and neck cancer involved disciplines to stress survival with acceptable late functional outcome and better health related quality of life. Therefore consideration of organ preservation moved from pure anatomical “organ in place” observation to late functional... Read More

Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids

Image   Gas signaling molecules (GSMs), composed of oxygen, carbon monoxide, nitric oxide, hydrogen sulfide, etc.play critical roles in regulating signal transduction and cellular homeostasis. Interestingly, through various administrations, these molecules also exhibit potential in cancer treatment. Recently, hydrogen gas (formula: H2) emerges as another GSM which possesses multiple bioactivities, including anti-inflammation, anti-reactive oxygen species, and anti-cancer. Growing evidence has shown that hydrogen gas can either alleviate the side effects caused by conventional chemotherapeutics, or suppress the growth of cancer cells and xenograft tumour, suggesting its broad patent application in clinical therapy. In the current review, we summarize... Read More

Bladder Cancer – A Cinderella Cancer: Advances and Remaining Research Questions

Image Bladder cancer is the 4th most common male cancer and 9th most common female malignancy. Despite its high incidence and prevalence, clinical outcomes have been static over the past 25 years. In 2010, bladder cancer care ranked 9th as the most expensive cancer in the USA with cumulative costs of 4 billion US dollars or 3.2% of all cancer-related care. A potential and significant contributing factor for the relative lack of improvement in the static mortality rate of BC is the small investment in bladder cancer. In the UK, prostate cancer research is supported with over £26,458,355 in funding and... Read More

Nurses Serve the Community

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage and reward our prospective audience which include clinicians, research scientists, decision-makers and a range of professionals. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of... Read More

Control of peripheral somatosensory neuron excitability

Image Mammalian somatosensory system is a bodily apparatus for perceiving and analyzing mechanical, thermal and chemical stimuli from the environment and viscera. Together with other senses, somatosensation is crucial for life as it feeds into and supports one’s momentary concept of the reality. Somatosensory system also serves another important function – it warns about imminent tissue damage (a sensation known as pain). Peripheral part of the somatosensory system consists of peripheral sensory neurons with cell bodies residing within the specific ganglia (e.g. dorsal root or trigeminal ganglia) and very long axons spreading throughout the body within sensory fibres. Peripheral terminals of... Read More

PAIN – Novel targets and new technologies

Image The problem of clinical pain management is complex and far-reaching, as it encompasses many different types of pain, such as arthritis, musculoskeletal conditions, neuropathic pain, and visceral pain. The analgesics market is growing and the driving forces are the aging population and need for better therapeutic benefits. There are various analgesic products that are available that can be administered by various routes, yet research is active in identifying new technologies for better drug targeting and novel targets to gain improved therapeutic efficiency. It is widely known that many of the well-established analgesic pathways are centrally based, involving spinal and... Read More

Targeted Subcellular Delivery of Anti-Cancer Agents

Image Anti-cancer pharmaceuticals that are practical to be delivered into specific subcellular compartment could be divided into at least two groups. The first comprises substances that show their effects only when delivered to a certain cell compartment, like DNA in the nucleus. There is a growing interest in. Anti-cancer pharmaceuticals that are practical to be delivered into specific subcellular compartment could be divided into at least two groups. The first comprises substances that show their effects only when delivered to a certain cell compartment, like DNA in the nucleus. There is a growing interest in targeted subcellular delivery of such... Read More

Cancer Care Delivery and Women's Health

Image Cancer care delivery refers to the multiple layers of the health care system that interact to affect outcomes for patients with cancer and the quality of that care. The factors included in the care delivery system that potentially alter outcomes include social dynamics, financing systems, organizational structures and processes, health technologies, provider and individual behaviors. Because women’s health care has its own unique challenges, the intersection between cancer care delivery and women’s health is to be examined in this Frontiers in Oncology issue. The unique opportunities and challenges of improving the health care system for women with breast and gynecologic... Read More

Hemostasis and Stroke

Image Stroke is the leading cause of death and permanent disability worldwide. Hemostasis abnormalities resulting in thrombosis of the cerebral vasculature lead to ischemic strokes, while unbalanced hemostasis resulting in bleeding is a key contributor to most hemorrhagic strokes. Stroke is the leading cause of death and permanent disability worldwide. Hemostasis abnormalities resulting in thrombosis of the cerebral vasculature lead to ischemic strokes, while unbalanced hemostasis resulting in bleeding is a key contributor to most hemorrhagic strokes. Despite best efforts to study the hemostatic system, specific alterations that predispose patients to stroke remain poorly defined, and the exact role played... Read More

Machine Learning and Decision Support in Stroke

Image Decision algorithms in acute stroke have continuously evolved over the last two decades to more precisely capture the heterogeneous distribution of this devastating disease. Clinical trials, as well as large scale retrospective studies, have demonstrated safe use of re-canalization therapy for prolonged time windows, refined perfusion–diffusion mismatch, core estimation, risk of haemorrhage, and better estimation of recovery. With the advent of genomics and personalized biomarkers, decision support algorithms in stroke will continue to be improved and increasingly rely on complex computational models. In recent years, the greater accessibility to large imaging and clinical datasets and the increased computational power... Read More

Geriatric Health

Image The global population is aging, and the growing awareness of the importance of promoting healthy aging is becoming increasingly relevant to physicians of many disciplines and fields of expertise. The complex issues affecting the health of older adults demand a multidisciplinary and coordinated personalized approach. The acquisition of an array of medical conditions and comorbidities with advancing age with a background of age-related physiological changes slowly diminishes functional and cognitive reserve. While health issues play a central role in this composite and interesting tapestry woven around the older adult, other facets become increasingly relevant. These include family... Read More

International Council of Nurses

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Formulation, Optimization and Evaluation of Glycerogelatin In Situ Film Containing Ethanolic Leaf Extract of Calotropis gigantea for Arthritis

Image The aim of the study was to design, optimize and evaluate transdermal glycerogelatin in situ film containing Calotropis gigantea leaves extract for the treatment of Arthritis. Skin is considered as an important route of administration for both local and systemic effects. Topical film forming systems are developing drug delivery system ment for topical application to the skin, which adhere to the body, forming a thin transparent elastic film which provide delivery of active ingredient to the body tissue. The formulation was optimized by mixture design (design... Read More

Nursing Care Plans for a Patient

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage and reward our prospective audience which include clinicians, research scientists, decision-makers and a range of professionals. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of... Read More

Molecular Characterization of Clinical Isolates to Study rpoB Gene in Mycobacterium tuberculosis Complex

Image One of the major health problems that can be seen around the world is Anti-microbial resistance and the main cause behind it, is easy availability and higher consumption of medicines. Rifampicin Resistance Tuberculosis (RRTB) occur when rpoB (RNA polymerase) gene in Mycobacterium tuberculosis (MTB) gets mutated and this rpoB gene encodes for beta-subunit of RNA polymerase. Clinical specimens including pulmonary and extra-pulmonary secretion were collected from patients and detected for Tuberculosis (TB) positive cases by targeting mpb64 (Mannose-Binding Protein) gene at 240 base pair. TB positive samples were taken to pre-amplification area for master-mix preparation for Polymerase Chain Reaction (PCR)... Read More

The Importance of Interneurons in Neuronal Circuitry

Image The diversity of interneurons in the central nervous system is striking. Only in the cortex, interneurons account for around 20% of all neurons; most of these cells are GABAergic and are morphologically and functionally diverse since they comprise no less than twenty-three different types. Indeed, the malfunction of some of these neurons has been associated with some neurological disorders such as depression, epilepsy or schizophrenia. In general, each interneuron type can be more effectively driven by a preferred stimulus; this diversity of activation thus broadens the operating range of the neuronal circuits. In this context, understanding the roles of... Read More

Nursing Home Care

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Clinical nursing. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage and reward... Read More

An important public health policy concern: Health disparities

Image Health disparities are an important public health policy concern as they are related to the social inequalities in population health. Health disparities are not just a problem for the persons experiencing them, but also a concern for the entire population in the society. Take the U.S. as an example; there are large health status gaps between racial groups, and the health of the racial minorities in the U.S. will negatively impact the overall health of the nation. Health disparities are also costly and particularly burdensome to the US healthcare system. A 2009 report on the economic burden of health disparities... Read More

Immunoglobulins

Image Immunoglobulins Immunoglobulins, also known as antibodies, are glycoprotein molecules produced by plasma cells (white blood cells). They act as a critical part of the immune response by specifically recognizing and binding to particular antigens, such as bacteria or viruses, and aiding in their destruction. The antibody immune response is highly complex and exceedingly specific. The various immunoglobulin classes and subclasses (isotypes) differ in their biological features, structure, target specificity and distribution. Hence, the assessment of the immunoglobulin isotype can provide useful insight into complex humoral immune response. Assessment and knowledge of immunoglobulin structure and classes is also important for selection... Read More

Advances in Plasma Cells in Health and Disease

Image Protective plasma cells (PCs) arise following infection and vaccination, and long-lived plasma cells (LLPCs) provide humoral protection for a lifetime. PCs are the resting, non-proliferative, terminally differentiated effectors of B cells that secrete protective antibodies decades following antigen encounter. In the blood, early antibody secreting cells (ASCs) eventually mature into LLPCs, but the specific molecular programs regulating this maturation process remain elusive. The phenotype of human LLPCs is currently defined as a CD19negCD138+CD38hi compartment. However, even within this well-defined population, these cells are likely to be heterogeneous. Size, ribosomal content and the metabolic status of the LLPC remain important questions.... Read More

The neuronal phase code

Image Recent progress in deciphering the relationship between spiking activity and brain rhythms (including the resonant properties of neurons) has revealed profound modulation of coherence between neurons within local and between distant structures. This modulation of coherence raises the question whether the phase of these oscillations may control spike flow in the brain much faster than slowly adapting synaptic modifications, as earlier thought. For example, the phase of local subthreshold oscillations affects the probability of neurons responding to input from other areas, thus the oscillations are capable of gating the information flow. In turn, the output information flow is then able... Read More

AUTOPHAGY

Image AUTOPHAGY The word autophagy is derived from Greek words “auto” meaning self and “phagy” meaning eating. Autophagy is a normal physiological process in the body that deals with destruction of cells in the body. It maintains homeostasis or normal functioning by protein degradation and turnover of the destroyed cell organelles for new cell formation. During cellular stress the process of Autophagy is upscaled and increased. Cellular stress is caused when there is deprivation of nutrients and/or growth factors. Thus Autophagy may provide an alternate source of intracellular building blocks and substrates that may generate energy to enable continuous cell survival.... Read More

Nursing and Caring Affordable Care Act

Image Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to clinical nursing and practice and has announced reasonable discounts in the publication charges. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage and reward our prospective audience which include clinicians,... Read More

What Are the Steps to Creating a Nursing Care Plan for Dementia Patients?

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. It gives us great pleasure to announce the call for paper on the occasion of Anniversary of the Journal at special and hefty discount of up... Read More

Keep Calm and Thank a Nurse

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with... Read More

Becoming a clinical nurse

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. The Editorial Board of Journal of clinical nursing and practices invites all the academic and research contributors to publish with the journal and take part in... Read More

Translating Systems Medicine into Clinical Practice

Image The medical research and clinical practice community has long recognized that many diseases and conditions are not homogeneous. While the concept of an “average” patient has been the status quo, we are starting to see the limitations of this practice in that the cost of developing new medications are escalating while the improvements of patient outcome through these treatments are marginal. Policy makers around the world are increasingly recognizing a need for meaningful improvements and in patient outcome that is at the same time economically sustainable, and are thus turning to systems medicine approaches to provide a solution. ... Read More

Biomedical Signals for Human-Computer Interaction

Image Biosignals have been extensively used in the medical domain for more than 200 years, with Electrocardiography (ECG) and Electroencephalography (EEG) being well-known examples. Over the past decades, the application of computer science and engineering principles to the field has proven to be of paramount importance, leading to remarkable technical, methodological and scientific achievements. Today, biosignals are a popular topic within the global research community, and potential applications are far-reaching within the medical arena, paving the way for the emerging field of Physiological Computing (PC). In an analogous way to that of physical computing, PC can be defined as the... Read More

Mitophagy in Health and Disease

Image Mitochondria, the indispensable and highly dynamic, energy-generating organelles in all eukaryotic cells, play essential roles in fundamental cellular processes, including calcium buffering, reactive oxygen species generation, ion homeostasis, lipid metabolism, cellular differentiation, cell death and apoptosis among others. Given the fact that mitochondria are the main sites of high metabolic activity and, hence, a hotspot of metabolic stress, it is not surprising that the impairment of their function is involved in the development and progression of a broad spectrum of pathological conditions. Thus, several and redundant quality control mechanisms have evolved to sustain and restore mitochondrial function, including mitochondrial biogenesis,... Read More

Precision Public Health

Image Traditional public health practice has had a central reliance on data, and the core discipline of epidemiology, in order to inform health policy and priority-setting, drive health improvement across whole populations, and target disadvantaged populations. Core activities include risk factor and disease surveillance, screening, development of interventions and evaluation. Since the 1970s, New Public Health has also emphasised community engagement, health promotion, partnerships and advocacy. In the last twenty years, and particularly with the sequencing of the human genome and advances in information communications technology, new possibilities are opening up for a much more finely delineated view... Read More

Nurses do it with love & care

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage and reward our... Read More

Vital role of Clinical Nursing and Practice in Health Sector

Image Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography and has announced a reasonable discounts in the publication charges.The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this... Read More

Nurses are Key to the Health of the Nation

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with... Read More

Know Symptoms of Cancer and get treated before

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the Anniversary and we are privileged to welcome Analytical Society to our European Journal of Clinical Oncology  Survivorship has become an important aspect of cancer care. With the development of targeted and multi-modality treatments, and more effective treatments generally, prolonged survival or even cure has become commonplace... Read More

Fertility, Pregnancy and Mental Health - a Behavioral and Biomedical Perspective

Image The survival and biological fitness of a species rely on its capacity to reproduce. In most animal species, the potential for successful reproduction depends on both the male and female physiological and mental health. While fertility and pregnancy have received attention from ancient times until this day, the investigation of the female’s fertility-pregnancy-brain-behavior axis has been limited. Female fertility is dependent on an extensive array of factors and has been regulated through the centuries, varying in methods. According to a recent CDC report, in the United States alone, in the years 2015-2017, approximately 65% of women... Read More

Medical Image Perception: How Much Do We Understand It?

Image Medical imaging is a core component in medical health care, and accounts for 40% of all UK hospital procedures. Clinical screening programmes for breast and colorectal cancer rely exclusive on medical imaging. The vast amount of imaging data produced by modalities such as CT and MRI, and other imaging technologies are rapidly changing the radiological task. Until the 1940’s radiologists assumed that the reports of trained specialists were a faithful representation of the images’ information content. In subsequent years the issue of observer error began to emerge as a critical factor. For example, it became clear that... Read More

Medical Imaging for Design and Biomechanical Optimisation of Personalised Medical Devices

Image Personalised medicine is tailored to individual patient needs and is gaining increased attention due to its benefits in reducing side effects and increasing treatment efficacy. Consequently, the demand for more personalised medical devices is growing rapidly and, with advancements in the integration of design, prototyping and manufacturing, personalised orthopedic therapies with improved treatment success and patient outcome are becoming more widely accessible. Classically, most medical devices, such as surgical implants, have been designed and manufactured on a mass scale, and are limited in their ranges of size and shape. Such limitations have triggered the quest to develop... Read More

Human and Artificial Collaboration for Medical Best Practices

Image One of the most critical issues related to the social and economic impact of artificial intelligence is work automation – and hence the possible disappearance of human jobs. However, just as important is the interaction between human work and artificial agents, which was immediately found to be relevant in medical practice, as a result of the progress made by the application of machine learning algorithms for both diagnostic and prognostic purposes. The promise is usually that application of these technologies will be positive in terms of accuracy, speed, economy and quality of the decision-making process. On the other hand, initial... Read More

Scope of Clinical nursing and practice

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to nursing. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with... Read More

Recent trends in Chemotherapy to cure cancer

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the  Anniversary and we are privileged to welcome Analytical Society to our journal. Scope of the journal:  It mainly encompasses topics Cancer Biology, prostate cancer, colorectal cancer, cancer Immuno therapy, chemotherapy, cancer radiology, therapeutic cancer, cancer pathology reaching out to analytical scientists worldwide. Journal accepts original manuscripts... Read More

Vital resource of Clinical nursing and practice

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge.Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part... Read More

Submissions open for Health and Medical Research

Image The Journal of Health and Medical Research (JHMR), now in its 2nd year, is the pioneer open access Health journal and is the flagship journal of Lexis Publications.   As an open access journal, we are read by clinicians, allied health professionals, informal caregivers, and patients alike, and have (as with all JHMR journals) a focus on readable and applied science reporting the design and evaluation of health innovations and emerging technologies. We publish original research, viewpoints, and reviews (both literature reviews and medical device/technology/app reviews).   We solicit your kind co-operation by not submitting plagiarized manuscripts. IHRJ has a... Read More

Platform to share knowledge in Cancer

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privileged to welcome Analytical Society to our journal. The European Journal of Clinical Oncology aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to oncology. The Journal is successfully running which covers a wide variety of specialties including strives to publish highest quality articles pertaining to clinical research, which are freely accessible to one... Read More

Clinical Nurse

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with... Read More

Cancer Survivorship Guidelines

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the Anniversary and we are privileged to welcome Analytical Society to our European Journal of Clinical Oncology  Survivorship has become an important aspect of cancer care. With the development of targeted and multi-modality treatments, and more effective treatments generally, prolonged survival or even cure has become commonplace... Read More

Evaluation of Serum Insulin Level as a Marker of Insulin Resistance | Health Research

Image Journal of Health and Medical Research has recently launched its volume 1 and the article entitled “Evaluation of Serum Insulin Level as a Marker of Insulin Resistance in Obese with and without Diabetes Type-2” was written by one of its editors Dutta S and Sanjay Bhatt S for its inaugural issue.   The article explains about Introduction: Insulin resistance is the greatest risk factor for development of obesity and Type-2 DM. Euglycemia with increased insulin level is one of the salient features in insulin resistance. Techniques for assessment of insulin resistance by HOMA, QUICKI are very tedious, expensive and time-consuming... Read More

Journal of Clinical Nursing and Practice submissions

Image We are pleased to announce a Call for Papers for a regular Issue of Journal of Clinical Nursing and practice with focus on Clinical-Academic Workforce Capacity Development. Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the Journal of clinical nursing and practice, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s been long years we have started the Journal, now we are celebrating and we are privileged to welcome Analytical Society to our journal. A clinical nurse specialist (CNS) is... Read More

Autoimmunity

Image Autoimmunity Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues. Any disease that results from such an aberrant immune response is termed an "autoimmune disease". Prominent examples include celiac disease, post-infectious IBS, diabetes mellitus type 1, Henloch Scholein Pupura (HSP) sarcoidosis, systemic lupus erythematosus (SLE), Sjögren's syndrome, eosinophilic granulomatosis with polyangiitis, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's disease, rheumatoid arthritis (RA), ankylosing spondylitis, polymyositis (PM), dermatomyositis (DM) and multiple sclerosis (MS). Autoimmune diseases are very often treated with steroids. The immune response in autoimmune disease recapitulates that of responses directed... Read More

Carcinogens

Image Carcinogens     In pathology, a carcinogen is any substance or agent that promotes cancer. Carcinogens are also often, but not necessarily, mutagens or teratogens. Carcinogens may cause cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with normal biological processes. Aflatoxin B1, which is produced by the fungus Aspergillus flavus growing on stored grains, nuts and peanut butter, is an example of a potent, naturally-occurring microbial carcinogen. Cooking protein-rich food at high temperatures, such as broiling or barbecuing meats, can lead to the formation of many potent carcinogens that are comparable to those found in... Read More

Chopped: The Salad Competiton Dietary Behaviors: Health Research

Image Journal of Health and Medical Research has published an article entitled “Chopped: The Salad Competiton Dietary Behaviors of Urban CollegeStudents” in its volume 1 Issue 3 written by Michele Montecalvo, Alexis L Holder, Rahim McNeilly, Marianne Ellis.   The article explains about the measure  the  dietary behaviors  of  urban  college  students  18  to  25,  with  an  evaluation  of  anutritional intervention “Chopped: The Salad Competition” by the American Heart Association. A convenience sample of 100 students engaged in an intervention and evaluation was used. Our sample reported 92.8% had a shift in eating habits since attending college. Notably, 80.7% reportedan interest... Read More

Journal of Health and Medical Research | Special Issue Guidelines

Image Journal of Health and Medical Research welcomes proposals for creating special issues that fall within the scope of the health sciences published by Lexis. The special issue aims at exploring new, relevant, and most compelling dimensions in the field of health and medical sciences that missed a mention in the journal on a regular basis.   Proposal Preparation Special issues will be released on a monthly basis and proposals will be accepted accordingly. All proposals should include the following information:   Title of the proposed special issue Purpose and current relevance List of topics to be covered List of... Read More

Introduction to Journal of Health and Medical Research

Image   JHMR is an open access, monthly, peer reviewed international journal with a primary objective to provide research and applications related to Medical & Health Sciences. Journal of Health and Medical Research (JHMR) aims to publish original research work that contributes significantly to enhance the scientific knowledge in Medical Sciences.   JHMR focus on Clinical Research, Epidemiology, Oncology, Biomedicine, Dentistry, Medical Education, Physiotherapy, Pulmonology, Nephrology, Gynaecology, Dermatology, Dermatoepidemiology, Otorhinolaryngology, Ophthalmology, Sexology, Osteology, Kinesiology, Neuroscience, Haematology, Psychology, Paediatrics, Angiology/Vascular Medicine, Critical care Medicine, Cardiology, Endocrinology, Gastroenterology, Infectious Diseases and Vaccinology, Hepatology, Geriatric Medicine, Bariatrics, Pharmacy and Nursing, Pharmacognosy and Phytochemistry, Radiobiology, Pharmacology,... Read More

Pediatric oncology

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the  Anniversary and we are privileged to welcome Analytical Society to our journal. Scope of the journal:  It mainly encompasses topics Cancer Biology, prostate cancer, colorectal cancer, cancer Immuno therapy, chemotherapy, cancer radiology, therapeutic cancer, cancer pathology reaching out to analytical scientists worldwide. Journal accepts original manuscripts... Read More

Journal of Pharmaceutical Sciences and Drug Development (JPSDD)

Image Pharmaceutical science contributed immensely in development of better medicines and has significant impact on the health care. The research and development focus in pharmaceutical science is increasing. Sharing of research outcomes as well as integrated scientific endeavors is fundamental for relatively faster development of new medicines, while avoiding redundancy. In this context, Journal of Pharmaceutical Sciences and Drug Development aims to broadcast scholarly research contributions pertaining to drug specificity, optimizing dosage regimen, drug delivery systems and regulation. The Journal caters to the updated information requirements of pharmacy students, health care providers as well as medical professionals. Please, follow the Instructions for... Read More

Journal of Pharmaceutical Sciences and Drug Development | Volume 2 Issue 1

Image Pharmaceutical science contributed immensely in development of better medicines and has significant impact on the health care. The research and development focus in pharmaceutical science is increasing. Sharing of research outcomes as well as integrated scientific endeavors is fundamental for relatively faster development of new medicines, while avoiding redundancy. In this context, Journal of Pharmaceutical Sciences and Drug Development aims to broadcast scholarly research contributions pertaining to drug specificity, optimizing dosage regimen, drug delivery systems and regulation. The Journal caters to the updated information requirements of pharmacy students, health care providers as well as medical professionals. Please, follow the Instructions for... Read More

Journal of Health and Medical Research: Call for papers

Image Journal of Health and Medical Research: Call for papers   Journal of Health and Medical Research is a peer-reviewed, open access journal designed for the wide dissemination of research in the field of medicine to worldwide audience. Medical Research covers the basic, applied and translational research conducted so as to aid and build knowledge in the field of medicine. This journal publishes articles from all areas of medical research of international interests. With an emphasis on conceptual breakthroughs and current trends, its goal is to facilitate towards developing new medicines and improving the application of the medical procedures, thereby improving... Read More

European Journal of Clinical Oncology announces reasonable discount

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the Anniversary and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the European journal of clinical oncology. The European journal of clinical European Journal of Clinical Oncology  aims to disseminate knowledge and... Read More

Instructions for authors for submissions: Journal of HIV and AIDS Research

Image Instructions for authors for submissions: Journal of HIV and AIDS Research Journal of HIV and AIDS Research is an open access peer reviewed journal within the field of medical sciences which publishes the eminent research in all the fields of medical and health sciences.  Journal is having the Editorial Submission and Review Tracking System which provides the easy and feasible way to submit and track the manuscript by author and they can easily access about the review comments of their paper through this Editorial Submission and Review Tracking System.  Types of manuscripts accepted by the Journal... Read More

Empathy and Caring plays major role in Clinical nursing and practice

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. The Editorial Board of Journal of clinical nursing and practices is overwhelmed by the response and eagerness of the academic and research contributors to publish with... Read More

Prevention of Oncology

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the  Anniversary and we are privileged to welcome Analytical Society to our journal. The European journal of European Journal of Clinical Oncology  aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to oncology. Oncology is a branch of medicine... Read More

Scope of Dental Research and Practice: Open Access Journal

Image Scope of Dental Research and Practice: Open Access Journal The Journal of Dental Research and Practice specially welcomes studies pertaining to clinical dentistry, and all basic science aspects of physiology, microbiology, structure, chemistry, and developmental biology of relevant oral tissues. In addition, studies evaluating the use of new drugs, new diagnostic strategies and treatments for various kinds of oral and maxillofacial defects, and new biomaterials are also encouraged. Moreover, studies pertaining to psychological interventions, oral health care for the elderly, and improvement of disease treatment outcomes are also solicited. The Journal of Dental Research and Practice is... Read More

Clinical nursing and practice

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. Currently, the Lexis group operates from its headquarters in Brussels, Belgium, and regional office in Hamburg, Germany. The Editorial Board of Journal of clinical nursing and... Read More

Clinical oncology

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the  Anniversary and we are privileged to welcome Analytical Society to our journal. The European journal of European Journal of Clinical Oncology  aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to oncology. The Journal is successfully running which... Read More

Inviting you to Join as an Editorial Board for Journal of HIV and AIDS Research: Open Access Journal

Image Inviting you to Join as an Editorial Board for Journal of HIV and AIDS Research: Open Access Journal   Journal of HIV and AIDS Research is one of the best open access journal that aims to publish the most complete and reliable source of information on discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in the field and provide free access through online without any restrictions or any other subscriptions to researchers worldwide. This top best scholarly journal is using Editorial Tracking System for quality in online manuscript submission,... Read More

Journal of Dental Research and Practice Announces Reasonable Discounts

Image Journal of Dental Research and Practice Announces Reasonable Discounts Journal of Dental Research and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Dental Research and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Dental research and practice. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. Currently, the Lexis group operates from its headquarters in Brussels, Belgium, and regional... Read More

About Journal of HIV and AIDS Research

Image About Journal of HIV and AIDS Research HIV infection remains incurable even today. Until a vaccine or effective cure is found, the greatest deterrent against HIV is the knowledge generated from systematic research. Several countries lack basic data sources to help researchers, non-governmental organizations (NGO) workers and policy implementers. In this context, Journal of HIV and AIDS Research draws attention of the readers to the latest developments in HIV research focused on prevention, treatment and cure. The journal encourages research articles, reviews, editorials, short communications, case reports and clinical trials. Scope Journal of HIV and AIDS Research... Read More

Immunological Response

Image Immunological Response   The Immune response is the body's response caused by its immune system being activated by antigens. The immune response can include immunity to pathogenic microorganisms and its products, allergies, graft rejections, as well as autoimmunity to self-antigens. The immune system protects the body from possibly harmful substances by recognizing and responding to antigens. Antigens are substances (usually proteins) on the surface of cells, viruses, fungi, or bacteria. Nonliving substances such as toxins, chemicals, drugs, and foreign particles (such as a splinter) can also be antigens. The immune system recognizes and destroys, or tries to destroy, substances that... Read More

Manuscript Submissions: Journal of Dental Research and Practice

Image Manuscript Submissions: Journal of Dental Research and Practice Journal of Dental Research and Practice is an open access peer reviewed journal within the field of medical sciences which publishes the eminent research in all the fields of medical and health sciences.    Journal is having the Editorial Submission and Review Tracking System which provides the easy and feasible way to submit and track the manuscript by author and they can easily access about the review comments of their paper through this Editorial Submission and Review Tracking System.  Manuscripts are subjected to rigorous peer review, where acclaimed scientists... Read More

IMMUNOPATHOLOGY

Image IMMUNOPATHOLOGY   Immunopathology is one's immune system reaction. Symptoms of immunopathology are unique to a patient and can include: fatigue, muscle weakness, rash, headache, photosensitivity, pain anywhere, numbness, nausea, diarrhea, constipation, ringing in the ears, toothache, sinus congestion, nasal stuffiness, fever/chills, flu-like bodyache, cough, irritability, depression, sleep disturbances and “brain fog.” Immunopathology (often abbreviated to IP) is what patients experience when they fight an infection. In the context of the Marshall Protocol, immunopathology refers to an increase in one's present symptoms of inflammation, or a return of previous inflammatory symptoms. This is caused by cytokines and endotoxins being released from... Read More

Journal of clinical nursing and practice for a healthier lifestyle

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. Currently, the Lexis group operates from its headquarters in Brussels, Belgium, and regional office in Hamburg, Germany. The Editorial Board of Journal of clinical nursing and... Read More

Instructions for authors for submissions: Journal of Dental Research and practice

Image Instructions for authors for submissions: Journal of Dental Research and practice Journal of Dental Research and practice is an open access peer reviewed journal within the field of medical sciences which publishes the eminent research in all the fields of medical and health sciences.  Journal is having the Editorial Submission and Review Tracking System which provides the easy and feasible way to submit and track the manuscript by author and they can easily access about the review comments of their paper through this Editorial Submission and Review Tracking System.  Types of manuscripts accepted by the Journal includes... Read More

Latest discoveries in clinical oncology

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the 1th Anniversary and we are privileged to welcome Analytical Society to our journal. The European journal of European Journal of Clinical Oncology  aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to oncology. The Journal is successfully running... Read More

Instructions for authors for submissions: Journal of Health and Medical Research

Image Journal of Health and Medical Research is an open access peer reviewed journal within the field of medical sciences which publishes the eminent research in all the fields of medical and health sciences.   Journal is having the Editorial Submission and Review Tracking System which provides the easy and feasible way to submit and track the manuscript by author and they can easily access about the review comments of their paper through this Editorial Submission and Review Tracking System.   Types of manuscripts accepted by the Journal includes Research,... Read More

Journal of clinical nursing and practice for a better tomorrow

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. Currently, the Lexis group operates from its headquarters in Brussels, Belgium, and regional office in Hamburg, Germany. The Editorial Board of Journal of... Read More

Journal of clinical nursing and practice

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Clinical Nursing and Practice aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. Currently, the Lexis group operates from its headquarters in Brussels, Belgium, and regional office in Hamburg, Germany. The Editorial Board of Journal of... Read More

Journal of Health and Medical Research has inviting eminent professors to join Editorial Board

Image Journal of Health and Medical Research is a newly launched Journal disseminating by the Lexis publisher to emphasize the scientific works within the field of Health and Medical Sciences. Journal of Health and Medical Research publishes articles covering wide range of disciplines including Biochemistry, Pharmacology and Toxicology focused on developing effective medicines, efficient procedures dealing both preclinical aspects like molecular and cellular research, in vitro and animal model studies as well as clinical trials. Health research topics relating to disease prevalence, risk factors, public health intervention outcomes as well as healthcare economics and medical research topics including... Read More

Latest innovation in clinical oncology

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the 1th Anniversary and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the European journal of clinical oncology. Oncology is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer. A medical professional who... Read More

Interferons- A Defensive Body

Image Interferons- A Defensive Body   Interferon are, any of several related proteins that are produced by the body’s cells as a defensive response to viruses. They are important modulators of the immune response. Interferon was named for its ability to interfere with viral proliferation. The various forms of interferon are the body’s most rapidly produced and important defense against viruses. Interferons can also combat bacterial and parasitic infections, inhibit cell division, and promote or impede the differentiation of cells. They are produced by all vertebrate animals and possibly by some invertebrates as well. Interferons are categorized as cytokines, small proteins... Read More

European journal of clinical oncology

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the 1th Anniversary and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the European journal of clinical oncology. Oncology is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer. A medical professional who... Read More

Dental Research and Practice | Volume 1 Issue 2

Image Dental Research and Practice | Volume 1 Issue 2 The Journal of Dental Research and Practice is an open access, peer-reviewed journal that is published keeping in mind the requirements of the dental community. The journal is dedicated to keeping its readers informed of the latest ideas, developments, opinions, and key issues in dentistry, be it clinical, practical, or scientific in order to spark interest and constructive discussion among dentists of all disciplines. Manuscripts may take the form of case reports, critical reviews of the literature, brief commentaries, meeting reports, innovations in clinical practice, letters and drug clinical trial studies.... Read More

Significance of Immune System

Image Significance of Immune System   The immune system is a complex network of cells and proteins that defends the body against infection. The immune system keeps a record of every germ (microbe) it has ever defeated so it can recognise and destroy the microbe quickly if it enters the body again. Our immune system is essential for our survival. Without an immune system, our bodies would be open to attack from bacteria, viruses, parasites, and more. It is our immune system that keeps us healthy as we drift through a sea of pathogens. This vast network of cells and tissues... Read More

Let the World Know Your Explorations In Dental Research

Image Let the World Know Your Explorations In Dental Research Journal of Dental Research and Practice is an international, peer-reviewed, open access journal that focuses on publishing novel topics in the field of dentistry. Manuscripts may take the form of case reports, critical reviews of the literature, brief commentaries, meeting reports, innovations in clinical practice, letters and drug clinical trial studies. JDRR welcomes direct submissions from authors: Attach your word file with e-mail and send it to: jdrp@dentistryjournals.org  alternatively to: dentalres@dentistryjournals.org Please, follow the Instructions for Authors. In the cover letter add the name... Read More

Development of Health and Medical Research for Long Similar to Successful Marathon Running

Image On the occasion of Inaugural issue, Editor of Journal of Health and Medical Research has submitted an editorial. The Journal of Health and Medical Research is thanking the editor for his immersive support to the Journal.   Editor Hiroshi Bando who is a Professor at Department of Medical Research, Tokushima University, Tokushima, Japan.   Editor has congratulated the journal on its inaugural issue and explained the role of medical journals has been important in the world, and it is necessary to widely cover health and medical research fields. A variety of research for human should be multifaceted, including bio-psycho-social, economic,... Read More

Journal of clinical nursing and practice announces discounts for upcoming issues

Image Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the Journal of clinical nursing and practice, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s been ten long years we have started the Journal, now we are celebrating and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of Chromatography and Separation Techniques. Journal of Clinical Nursing and Practice aims to disseminate... Read More

New innovation for the treatment of oncology

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the 1th Anniversary and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the European journal of clinical oncology. The European journal of clinical European Journal of Clinical Oncology  aims to disseminate knowledge... Read More

Journal of Pharmaceutical Sciences and Drug Development

Image Journal of Pharmaceutical Sciences and Drug Development has announced almost 50% discount on article processing charges (APC) to commemorate its 1st Anniversary. Editor-in-Chief David Gortler is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Journal of Pharmaceutical Sciences and Drug Development solicits research contributions pertaining to drug design, drug discovery, natural products, formulation, personalized medicine, testing the efficacy of drug molecule in vitro and in vivo, pharmacokinetics, pharmacogenomics, analytical sciences, nanotechnology, therapeutic aspects, quality control,... Read More

Journal Of Clinical Nursing And Practice Announces Reasonable Discounts

Image Journal Of Clinical Nursing And Practice Announces Reasonable Discounts Visakhapatnam, 05-12-2019 Journal of Clinical Nursing and Practice has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the Journal of clinical nursing and practice, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s been ten long years we have started the Journal, now we are celebrating and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of Chromatography and Separation Techniques.... Read More

European Journal of Clinical Oncology announces reasonable discounts

Image European Journal of Clinical Oncology has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. On behalf of the European journal of clinical oncology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we have started the Journal, now we are celebrating the 1th Anniversary and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the European journal of clinical oncology. The European journal of clinical European Journal of Clinical Oncology  aims to disseminate knowledge... Read More

Journal of Health and Medical Research has released its Inaugural Issue

Image Journal of Health and Medical Research has released inaugural issue for the year 2019, and has published nearly 7 quality articles in its inaugural issue. 30+ editors were added as editorial board members and took the opportunity to review the articles. The articles released in the inaugural issue includes: Development of Health and Medical Research for Long Similar to Successful Marathon Running Effect of Exercises Training on Fatigue, Depression and Physical Activity in Patients with Systemic Lupus... Read More

Journal of Dental Research and Practice partners with Research Institutes to improve research sharing.

Image Journal of Dental Research and Practice partners with Research Institutes to improve research sharing.   With the successful completion of its inaugural issue, Journal of Dental Research and Practice (JDRP) is now heading towards it upcoming Issue with wide feathers. Journal of Dental Research and Practice has been started with an aim to serve the scientists, practicing physicians, scholars and authors in the field of Dental Research by providing access to novel explorations in the field of Dental research. To help us achieve our aim, our eminent Editorial Board members have... Read More

Journal of Health and Medical Sciences announces discounts for Upcoming issue

Image With increasing life expectancy, globalization, life style changes, climate changes and changing demography, the global health care sector is facing new challenges. This is compounded by the prevalence of virulent infections and development of antibiotic resistance. In order to address these issues, health and medical research assumes central importance. In this context, Journal of Health and Medical Research provides a global platform for facilitating and promoting health and medical research communications, exchange of research concepts, sharing of recent developments, observations, expert opinions and innovative concepts as well as coordinated scientific programs. With open accessibility, the journal aims to provide inspiration... Read More

Annals of Microbiology & Immunology

Image Annals of Microbiology & Immunology   On behalf of the Journal of Microbiology and Immunology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s a newly started Journal, and we are offering a hefty discount of up to 50% on processing charges to microbiological & immunological Society. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of Microbiology and Immunology (JMBI). The Journal of Microbiology and Immunology aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography.... Read More

Journal of Pharmaceutical Sciences and Drug Development: An open access peer-reviewed Journal

Image  Journal of Pharmaceutical Sciences and Drug Development has announced almost 50% discount on article processing charge to commemorate its 1st Anniversary. The Editorial Board of Journal of Pharmaceutical Sciences and Drug Development is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage and reward our prospective audience which include clinicians, research scientists, decision-makers and a range of professionals in the healthcare community. Journal of Pharmaceutical Sciences and Drug Development (JPSDD) is an... Read More

Advances in Microbiology & Immunology for a Better Tomorrow

Image Advances in Microbiology & Immunology for a Better Tomorrow Journal of Microbiology and Immunology (Lexis Publisher) has announced almost 50% discount on article processing charges. The Editorial Board of Journal of Microbiology and Immunology had proposed the hefty concession in order to motivate new researchers who want to publish their work. During this year we look forward to taking some initiatives to encourage our fresh researchers and reward our audience which include clinicians, research scientists, decision-makers and professionals in the healthcare community. Journal of Microbiology and Immunology (JMBI) is an open access, peer-reviewed journal that focuses... Read More

UNCOVER NOVEL FACT FINDINGS WITH JOURNAL OF DENTAL RESEARCH AND PRACTICE

Image UNCOVER NOVEL FACT FINDINGS WITH JOURNAL OF DENTAL RESEARCH AND PRACTICE Journal of Dental Research and Practice is helmed by extremely talented Editorial Board Members with an aim to support our mission, values, and commitment to providing a high-quality experience to our authors. JDRP is an open-access journal that investigates and publishes articles of provocative issues and perspectives in the field of Dental research, reflecting global practices. The Journal of Dental Research and Practice is an open access, peer-reviewed journal that is published keeping in mind the requirements of the dental... Read More

Complementary And Alternative Medicine Practitioner’s Management Of Acute Respiratory Tract Infections In Children

Image Journal of Health and Medical Research is a newly launched Journal Announcing Discounts on Article Processing Charges    Journal of Health and Medical Research (Lexis Publishing) has announced almost 50 percent discount on article processing charge to commemorate its upcoming volume. The Editorial Board of Journal of Health and Medical Research is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage and reward our prospective audience... Read More