Organ Preservation in Treatment of Head and Neck Cancers

Image Organ preservation with acceptable late functional outcome is becoming the most favourable goal in head and neck cancer treatment since awareness of “coming back to life”-needs of survivors increased. Patient age dropped down especially in ororpharynx cancer in the last years mainly due to HPV. Growing literature regarding rehabilitation, late functional outcome and toxicity is focusing this issue strongly and pushing all in head and neck cancer involved disciplines to stress survival with acceptable late functional outcome and better health related quality of life. Therefore co... Read More

Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids

Image   Gas signaling molecules (GSMs), composed of oxygen, carbon monoxide, nitric oxide, hydrogen sulfide, etc.play critical roles in regulating signal transduction and cellular homeostasis. Interestingly, through various administrations, these molecules also exhibit potential in cancer treatment. Recently, hydrogen gas (formula: H2) emerges as another GSM which possesses multiple bioactivities, including anti-inflammation, anti-reactive oxygen species, and anti-cancer. Growing evidence has shown that hydrogen gas can either alleviate the side effects caused by conv... Read More

Bladder Cancer – A Cinderella Cancer: Advances and Remaining Research Questions

Image Bladder cancer is the 4th most common male cancer and 9th most common female malignancy. Despite its high incidence and prevalence, clinical outcomes have been static over the past 25 years. In 2010, bladder cancer care ranked 9th as the most expensive cancer in the USA with cumulative costs of 4 billion US dollars or 3.2% of all cancer-related care. A potential and significant contributing factor for the relative lack of improvement in the static mortality rate of BC is the small investment in bladder cancer. In the UK, prostate cancer research is supported with over £26,458,355 in f... Read More

Hemostasis and Stroke

Image Stroke is the leading cause of death and permanent disability worldwide. Hemostasis abnormalities resulting in thrombosis of the cerebral vasculature lead to ischemic strokes, while unbalanced hemostasis resulting in bleeding is a key contributor to most hemorrhagic strokes. Stroke is the leading cause of death and permanent disability worldwide. Hemostasis abnormalities resulting in thrombosis of the cerebral vasculature lead to ischemic strokes, while unbalanced hemostasis resulting in bleeding is a key contributor to most hemorrhagic strokes. Despite best efforts to study the hemo... Read More

Machine Learning and Decision Support in Stroke

Image Decision algorithms in acute stroke have continuously evolved over the last two decades to more precisely capture the heterogeneous distribution of this devastating disease. Clinical trials, as well as large scale retrospective studies, have demonstrated safe use of re-canalization therapy for prolonged time windows, refined perfusion–diffusion mismatch, core estimation, risk of haemorrhage, and better estimation of recovery. With the advent of genomics and personalized biomarkers, decision support algorithms in stroke will continue to be improved and increasingly rely on complex comp... Read More

The Importance of Interneurons in Neuronal Circuitry

Image The diversity of interneurons in the central nervous system is striking. Only in the cortex, interneurons account for around 20% of all neurons; most of these cells are GABAergic and are morphologically and functionally diverse since they comprise no less than twenty-three different types. Indeed, the malfunction of some of these neurons has been associated with some neurological disorders such as depression, epilepsy or schizophrenia. In general, each interneuron type can be more effectively driven by a preferred stimulus; this diversity of activation thus broadens the operating ran... Read More

The neuronal phase code

Image Recent progress in deciphering the relationship between spiking activity and brain rhythms (including the resonant properties of neurons) has revealed profound modulation of coherence between neurons within local and between distant structures. This modulation of coherence raises the question whether the phase of these oscillations may control spike flow in the brain much faster than slowly adapting synaptic modifications, as earlier thought. For example, the phase of local subthreshold oscillations affects the probability of neurons responding to input from other areas, thus the oscillatio... Read More