The virus destroys the body's immune system by infecting CD4 positive (CD4 +) T cells when a person contracts HIV. By preventing the HIV virus from killing CD4 + T cells, CART suppresses HIV infection, helping the body's immune system to develop an immune response and prevent the progression of AIDs. Individuals receiving cART care have, however, been reported to experience neurocognitive disorders associated with HIV, such as thought and memory issues. This is thought to be due to brain astrocytes, which help brain cell communication and protect the blood-brain barrier, becoming infected with HIV within 8 days of infection. Some researchers' findings of the experiment showed that the HIV virus was able to spread from transplanted astrocytes infected with HIV to CD4 + T cells in the brain, which then migrated to peripheral organs such as the spleen and lymph nodes and spread the infection. When mice were undergoing cART, this was also evident at lower levels. As shown by the identification of HIV DNA / RNA in the spleen, the cART disruption resulted in a rebound of HIV infection. HIV remains a significant public health concern globally, affecting 30-40 million individuals around the world. We need to truly understand how HIV impacts the brain and other tissue-based reservoirs in order to benefit patients. While there is a need for further research that reproduce these results, this study takes us another step closer to that understanding. This review tells about the future scope of the new invention towards the field of HIV /AIDS and their medicinal treatment. People who are interested can send their article towards our journal for publication through this https://www.scholarscentral.org/submissions/hiv-aids-research.html