Chlorhexidine has been widely used as an antiseptic agent in dental practice since 1970, owing to its long-lasting antibacterial efficacy with a wide range of action. In several studies using in vitro methods documenting positive results of CHX in reducing the proliferation of bacterial species associated with parodontal disease, such as Enterobacteria, Porphyromonas gingivalis, Fusobacterium nucleatum and various Actinomyces and Streptococcus species, including Streptococcus mutans, which are known to be the major etiological agent of dental caries. The use of CHX was effective in the treatment of halitosis, especially in reducing the levels of halitosis-related bacteria colonising the dorsal surface of the tongue. This study indicates that a 7-day use of CHX mouthwash has a significant impact on the oral microbiome, as well as shift to an acidic environment, favourable for increased dental caries, and a reduction of the amount of oral nitrate-reducing bacteria, which contribute to cardiovascular health. JDRP is an open access peer review journal who publishes different types of articles related to the field of dental or tooth problems, its cure, diagnosis and treatment. People who are interested in submitting their article can go through the URL link https://www.lexispublisher.com/online-submission.html